Linked Life Data

9347341

Source:http://linkedlifedata.com/resource/pubmed/id/9347341

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1997-12-4
pubmed:abstractText
1. Total saponin fraction at doses of 0.1 to 1.0 microgram, which administered IT alone did not affect the latencies of the tail-flick threshold, dose dependently attenuated inhibition of the tail-flick response induced by ICV-administered morphine (2 micrograms). 2. Total saponin fraction at doses of 1 to 20 micrograms, which administered ICV alone did not affect the latencies of the tail-flick response, did not affect ICV-administered morphine-induced antinociception. 3. The duration of antagonistic action of the total saponin fraction against morphine-induced antinociception lasted for at least 6 hrs. 4. Various doses of ginsenosides Rb2, Rc, Rd and Rg1, but not Rb1 and Re, injected IT dose dependently attenuated antinociception induced by morphine administered ICV. 5. In summary, ginsenosides Rb2, Rc, Rd and Rg1 injected spinally appear to have antagonistic action against the antinociception induced by supraspinally applied morphine. On the other hand, the total ginseng fraction, at supraspinal sites, may not have an antagonistic action against the antinociception induced by morphine administered supraspinally.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0306-3623
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
873-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Effects of ginsenosides injected intrathecally or intracerebroventricularly on antinociception induced by morphine administrated intracerebroventricularly in the mouse.
pubmed:affiliation
Department of Pharmacology, College of Medicine, Hallym University, Chunchon, Kangown-Do, S. Korea. HWSUH@SUN.HALLYM.AC.KR
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't