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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1997-11-17
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pubmed:databankReference |
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pubmed:abstractText |
FK 506-binding protein (FKBP) is an immunosuppressant mediator in mammals, but its endogenous physiological function has yet to be determined. Here we report a Xenopus homolog of FKBP, which is expressed at early stages of development. Injection of synthesized Xenopus FKBP mRNA, as well as murine constitutively active calcineurin, induced a secondary axis in Xenopus embryos, while an FKBP mutant which does not bind to calcineurin did not. This secondary-axis-inducing effect was inhibited when FKBP was coinjected with Xmad 1 or XBMP 4 mRNA. These results suggest that FKBP modifies BMP 4 signalling by recruiting calcineurin and may have an important role in axis formation during Xenopus development.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/BMP4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Bmp4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Protein 4,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Heat-Shock Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Smad Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tacrolimus Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Xenopus Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/bmp4 protein, Xenopus
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 1997 Academic Press.
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
239
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
585-91
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9344875-Amino Acid Sequence,
pubmed-meshheading:9344875-Animals,
pubmed-meshheading:9344875-Body Patterning,
pubmed-meshheading:9344875-Bone Morphogenetic Protein 4,
pubmed-meshheading:9344875-Bone Morphogenetic Proteins,
pubmed-meshheading:9344875-Carrier Proteins,
pubmed-meshheading:9344875-Cloning, Molecular,
pubmed-meshheading:9344875-DNA-Binding Proteins,
pubmed-meshheading:9344875-Embryo, Nonmammalian,
pubmed-meshheading:9344875-Heat-Shock Proteins,
pubmed-meshheading:9344875-Humans,
pubmed-meshheading:9344875-Mice,
pubmed-meshheading:9344875-Microinjections,
pubmed-meshheading:9344875-Molecular Sequence Data,
pubmed-meshheading:9344875-RNA, Messenger,
pubmed-meshheading:9344875-Signal Transduction,
pubmed-meshheading:9344875-Smad Proteins,
pubmed-meshheading:9344875-Tacrolimus Binding Proteins,
pubmed-meshheading:9344875-Trans-Activators,
pubmed-meshheading:9344875-Xenopus,
pubmed-meshheading:9344875-Xenopus Proteins
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pubmed:year |
1997
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pubmed:articleTitle |
Xenopus FK 506-binding protein homolog induces a secondary axis in frog embryos, which is inhibited by coexisting BMP 4 signaling.
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pubmed:affiliation |
Institute of Medical Science, University of Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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