| pubmed-article:9344703 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9344703 | lifeskim:mentions | umls-concept:C0003323 | lld:lifeskim |
| pubmed-article:9344703 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:9344703 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:9344703 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:9344703 | lifeskim:mentions | umls-concept:C1819882 | lld:lifeskim |
| pubmed-article:9344703 | lifeskim:mentions | umls-concept:C1522538 | lld:lifeskim |
| pubmed-article:9344703 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:9344703 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:9344703 | pubmed:dateCreated | 1997-12-16 | lld:pubmed |
| pubmed-article:9344703 | pubmed:abstractText | It has been previously demonstrated that the occupancy of CD4 molecules by the HIV-1 envelope glycoprotein gp120 results in marked inhibition of T cell receptor-CD3 complex (TCR/CD3) activation-induced IL-2 secretion. To elucidate the mechanism of inhibitory effects of gp160 on T cell signaling, we have investigated the intracellular biochemical events and biological output in response to anti-CD3 mAb activation of purified peripheral blood CD4+ T cells from healthy donors with and without prior exposure to HIV-1 gp160. Pretreatment with gp160 resulted in marked inhibition of tyrosine phosphorylation of p59(fyn), PLC-gamma1, ras activation, and TNF-alpha secretion in anti-CD3 mAb activated CD4+ T cells, and a subset of CD4+ cells underwent activation-induced cell death. The data presented here provide insight into the mechanism by which the interaction of HIV-1 envelope glycoproteins with CD4 molecules may alter TCR/CD3-activation-induced signal transduction resulting in anergy and apoptosis with consequent functional deficiency of CD4+ T cells. | lld:pubmed |
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| pubmed-article:9344703 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9344703 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9344703 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9344703 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:9344703 | pubmed:issn | 0090-1229 | lld:pubmed |
| pubmed-article:9344703 | pubmed:author | pubmed-author:KalyanaramanV... | lld:pubmed |
| pubmed-article:9344703 | pubmed:author | pubmed-author:PahwaSS | lld:pubmed |
| pubmed-article:9344703 | pubmed:author | pubmed-author:OyaizuNN | lld:pubmed |
| pubmed-article:9344703 | pubmed:author | pubmed-author:McCloskeyT... | lld:pubmed |
| pubmed-article:9344703 | pubmed:author | pubmed-author:ChirmuleNN | lld:pubmed |
| pubmed-article:9344703 | pubmed:author | pubmed-author:TammaS MSM | lld:pubmed |
| pubmed-article:9344703 | pubmed:copyrightInfo | Copyright 1997 Academic Press. | lld:pubmed |
| pubmed-article:9344703 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9344703 | pubmed:volume | 85 | lld:pubmed |
| pubmed-article:9344703 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9344703 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9344703 | pubmed:pagination | 195-201 | lld:pubmed |
| pubmed-article:9344703 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:9344703 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9344703 | pubmed:articleTitle | Signals transduced through the CD4 molecule interfere with TCR/CD3-mediated ras activation leading to T cell anergy/apoptosis. | lld:pubmed |
| pubmed-article:9344703 | pubmed:affiliation | Department of Pediatrics, North Shore University Hospital-New York University School of Medicine, Manhasset, New York 11030, USA. | lld:pubmed |
| pubmed-article:9344703 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9344703 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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