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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1997-11-20
|
| pubmed:abstractText |
This study examined rates of concomitant structural and chromosomal abnormalities in 14 fetuses with a diagnosis of Dandy-Walker malformation or Dandy-Walker variant before 21 weeks' gestational age, compared to 14 fetuses with a diagnosis of Dandy-Walker malformation or variant between 21 weeks' gestation and delivery. A total of 24 fetuses had Dandy-Walker malformation and four had Dandy-Walker variant. Eight of the fetuses with the malformation had ventriculomegaly: one of the fetuses with early diagnosis and seven with later diagnosis (p = 0.027). None of the fetuses with Dandy-Walker variant had ventriculomegaly. The overall prevalence of concomitant structural abnormalities was 13/28; 8/14 for fetuses with early prenatal diagnosis and 5/14 for fetuses with late prenatal diagnosis of the malformation or the variant. Chromosomal abnormality rates were significantly higher among fetuses with early prenatal diagnosis (7/14) than among those with later prenatal diagnosis (1/14; p = 0.032). Abnormal karyotypes were more prevalent among fetuses without ventriculomegaly (7/20), compared to fetuses with ventriculomegaly (1/8). We conclude that fetuses with an antenatal diagnosis of Dandy-Walker malformation or Dandy-Walker variant before 21 weeks' gestational age have worse prognosis than fetuses with a later prenatal diagnosis of the same defect.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0960-7692
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
10
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
167-70
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9339523-Adult,
pubmed-meshheading:9339523-Chromosome Aberrations,
pubmed-meshheading:9339523-Chromosome Disorders,
pubmed-meshheading:9339523-Chromosomes, Human, Pair 13,
pubmed-meshheading:9339523-Chromosomes, Human, Pair 18,
pubmed-meshheading:9339523-Confidence Intervals,
pubmed-meshheading:9339523-Dandy-Walker Syndrome,
pubmed-meshheading:9339523-Diagnosis, Differential,
pubmed-meshheading:9339523-Female,
pubmed-meshheading:9339523-Fetal Death,
pubmed-meshheading:9339523-Fetal Diseases,
pubmed-meshheading:9339523-Gestational Age,
pubmed-meshheading:9339523-Humans,
pubmed-meshheading:9339523-Infant, Newborn,
pubmed-meshheading:9339523-Intracranial Arteriovenous Malformations,
pubmed-meshheading:9339523-Pregnancy,
pubmed-meshheading:9339523-Pregnancy Outcome,
pubmed-meshheading:9339523-Retrospective Studies,
pubmed-meshheading:9339523-Sensitivity and Specificity,
pubmed-meshheading:9339523-Trisomy,
pubmed-meshheading:9339523-Ultrasonography, Prenatal
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Dandy-Walker malformation diagnosed before 21 weeks of gestation: associated malformations and chromosomal abnormalities.
|
| pubmed:affiliation |
Department of Obstetrics and Gynecology, University Hospital of Vienna, Austria.
|
| pubmed:publicationType |
Journal Article,
Comparative Study
|