| pubmed-article:9338103 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9338103 | lifeskim:mentions | umls-concept:C0212694 | lld:lifeskim |
| pubmed-article:9338103 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:9338103 | pubmed:dateCreated | 1997-11-14 | lld:pubmed |
| pubmed-article:9338103 | pubmed:abstractText | The DNA dependent protein kinase (DNA-PK) is a trimeric nuclear complex consisting of a large protein kinase and the Ku heterodimer that regulates kinase activity by its association with DNA. Recent findings have shown structural similarities between DNA-PK and a family of lipid and putative protein kinases (PIK family). DNA-PK is one of the PIK members known to be a protein kinase with clearly identified effector subunits. A broad range of observations link DNA-PK to dual roles in double strand DNA break (DSB) repair and transcription. Unlike its most closely related PIKs, DNA-PK is not required for activating cell cycle regulated DNA damage signalling mechanisms. Instead, the phenotypes and biochemical properties of DNA-PK are most consistent with functions in DSB repair and joining steps in recombination mechanisms. DNA-PK is associated with RNA polymerase II and RNA polymerase I transcription complexes, where it most frequently has a negative regulatory role. | lld:pubmed |
| pubmed-article:9338103 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9338103 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9338103 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9338103 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9338103 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9338103 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9338103 | pubmed:issn | 0261-2429 | lld:pubmed |
| pubmed-article:9338103 | pubmed:author | pubmed-author:InoueSS | lld:pubmed |
| pubmed-article:9338103 | pubmed:author | pubmed-author:JitII | lld:pubmed |
| pubmed-article:9338103 | pubmed:author | pubmed-author:WeaverD TDT | lld:pubmed |
| pubmed-article:9338103 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9338103 | pubmed:volume | 29 | lld:pubmed |
| pubmed-article:9338103 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9338103 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9338103 | pubmed:pagination | 221-61 | lld:pubmed |
| pubmed-article:9338103 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:9338103 | pubmed:meshHeading | pubmed-meshheading:9338103-... | lld:pubmed |
| pubmed-article:9338103 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9338103 | pubmed:articleTitle | Functions of the DNA dependent protein kinase. | lld:pubmed |
| pubmed-article:9338103 | pubmed:affiliation | Division of Tumour Immunology, Dana-Farber Cancer Institute, Boston, MA 02115, USA. | lld:pubmed |
| pubmed-article:9338103 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9338103 | pubmed:publicationType | Review | lld:pubmed |
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