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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1997-11-14
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pubmed:abstractText |
The DNA dependent protein kinase (DNA-PK) is a trimeric nuclear complex consisting of a large protein kinase and the Ku heterodimer that regulates kinase activity by its association with DNA. Recent findings have shown structural similarities between DNA-PK and a family of lipid and putative protein kinases (PIK family). DNA-PK is one of the PIK members known to be a protein kinase with clearly identified effector subunits. A broad range of observations link DNA-PK to dual roles in double strand DNA break (DSB) repair and transcription. Unlike its most closely related PIKs, DNA-PK is not required for activating cell cycle regulated DNA damage signalling mechanisms. Instead, the phenotypes and biochemical properties of DNA-PK are most consistent with functions in DSB repair and joining steps in recombination mechanisms. DNA-PK is associated with RNA polymerase II and RNA polymerase I transcription complexes, where it most frequently has a negative regulatory role.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0261-2429
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
221-61
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9338103-Animals,
pubmed-meshheading:9338103-Apoptosis,
pubmed-meshheading:9338103-Cell Cycle,
pubmed-meshheading:9338103-Cell Line,
pubmed-meshheading:9338103-DNA Damage,
pubmed-meshheading:9338103-DNA Repair,
pubmed-meshheading:9338103-DNA-Activated Protein Kinase,
pubmed-meshheading:9338103-DNA-Binding Proteins,
pubmed-meshheading:9338103-Drosophila,
pubmed-meshheading:9338103-Humans,
pubmed-meshheading:9338103-Mammals,
pubmed-meshheading:9338103-Mutagenesis,
pubmed-meshheading:9338103-Nuclear Proteins,
pubmed-meshheading:9338103-Phosphorylation,
pubmed-meshheading:9338103-Protein-Serine-Threonine Kinases,
pubmed-meshheading:9338103-Telomere,
pubmed-meshheading:9338103-Transcription, Genetic,
pubmed-meshheading:9338103-Yeasts
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pubmed:year |
1997
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pubmed:articleTitle |
Functions of the DNA dependent protein kinase.
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pubmed:affiliation |
Division of Tumour Immunology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
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pubmed:publicationType |
Journal Article,
Review
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