Linked Life Data

9332730

Source:http://linkedlifedata.com/resource/pubmed/id/9332730

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1998-2-17
pubmed:abstractText
Neuropeptide Y (NPY) is one of the most abundant peptides found in the mammalian central nervous system (CNS) and plays several important roles in regulating brain function. Physiological roles of NPY in the brain are mediated by at least six receptor subtypes (Y1 to Y6). In the present study, a rat Y1 receptor cRNA probe was used for in in situ hybridization experiments in order to determine the developmental profile of this receptor mRNA and to compare it with its translated protein using receptor autoradiography with the radiolabelled ligand [125I][Leu31,Pro34]PYY. The NPY Y1 receptor mRNA is expressed as early as by the 12th day of gestation while specific [125I][Leu31,Pro34]PYY binding is observed by day 14 of gestation. Thereafter, both signals steadily increased, with Y1 receptor mRNA increasing faster than its translated protein during fetal life. The in situ hybridization signals reached a plateau around birth and remained high during the first 2 post-natal weeks to display the adult distribution by the end of the 3rd post-natal week. Similarly, specific [125I][Leu31,Pro34]PYY binding constantly increased during brain maturation and reached a plateau by the end of the 3rd post-natal week. In some brain areas, such as the cerebral cortex, specific binding declined slightly before attaining its adulthood pattern. Throughout ontogenesis, the profile of both the Y1 receptor mRNA and protein was well-matched except in hypothalamic areas where relatively higher mRNA signals were observed. Taken together, these results along with previous reports describing NPY-like immunoreactivity in the early developmental rat brain, suggest that the NPY Y1 receptor may play an important role in early brain development and maturation on the basis of its very early pattern of embryonic expression.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0169-328X
pubmed:author
pubmed:issnType
Print
pubmed:volume
48
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
323-32
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Comparative developmental profile of the neuropeptide Y Y1 receptor gene and protein in the rat brain.
pubmed:affiliation
Douglas Hospital Research Center, Department of Psychiatry, McGill University, Verdun, Qué., Canada.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't