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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1997-10-30
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pubmed:abstractText |
The current goal of thrombolytic therapy is to achieve both full (Thrombolysis in Myocardial Infarction [TIMI] grade 3) and early reperfusion. Newer reperfusion strategies may now achieve a high degree of reperfusion even earlier than the traditional 90-minute end point. To determine whether injections before 90 minutes affect this traditional end point, the relation between the number of injections before 90-minute angiography and patency was examined in the TIMI 4 trial. The number of injections before 90-minute angiography was no different between occluded arteries (TIMI grade 0/1 flow) (2.46 +/- 1.78; n = 94) and patent arteries (TIMI grade 2/3 flow) (2.71 +/- 2.42; n = 295) (p = 0.24). The incidence of any injections before 90 minutes was no different in patent versus closed arteries (80.6% [77/98] vs 72.4% [22/304]; p = 0.10). The number of injections before 90 minutes was insignificantly smaller in patients with TIMI grade 3 flow (2.53 +/- 2.53 [n = 184] vs 2.76 +/- 2.03 [n = 204]; p = 0.31), but the incidence of any injections before 90 minutes was significantly smaller in patients with TIMI grade 3 flow (68.8% [132/192] vs 79.5% [167/210]; p = 0.01). No relation was identified between the number of injections before 90-minute angiography and patency at this traditional time point. This observation justifies the judicious use of a limited number of "earlier snapshots" of the infarct-related artery before 90 minutes to ascertain just how rapidly newer thrombolytic regimens achieve patency. Patients with TIMI grade 3 flow had a slightly lower incidence of injections before 90 minutes, perhaps because they did not require as urgent a definition of coronary anatomy.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0002-8703
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
134
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
351-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9327688-Aged,
pubmed-meshheading:9327688-Constriction, Pathologic,
pubmed-meshheading:9327688-Coronary Angiography,
pubmed-meshheading:9327688-Coronary Vessels,
pubmed-meshheading:9327688-Female,
pubmed-meshheading:9327688-Fibrinolytic Agents,
pubmed-meshheading:9327688-Humans,
pubmed-meshheading:9327688-Male,
pubmed-meshheading:9327688-Middle Aged,
pubmed-meshheading:9327688-Myocardial Infarction,
pubmed-meshheading:9327688-Myocardial Reperfusion,
pubmed-meshheading:9327688-Retrospective Studies,
pubmed-meshheading:9327688-Thrombolytic Therapy,
pubmed-meshheading:9327688-Time Factors,
pubmed-meshheading:9327688-Treatment Outcome,
pubmed-meshheading:9327688-Vascular Patency
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pubmed:year |
1997
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pubmed:articleTitle |
Relation between injections before 90-minute angiography and coronary patency: results of the thrombolysis in myocardial infarction 4 trial.
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pubmed:affiliation |
Department of Medicine, Brigham and Women's Harvard Medical School, Boston, USA.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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