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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
|
pubmed:dateCreated |
1976-9-1
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pubmed:abstractText |
Radioactive sulfate-35 (35S) was administered to eight human subjects intravenously and orally, to compare respective kinetics of distribution. Intravenously administered 35S attained equilibration within 60-90 min. Orally administered 35S attained equilibration within 60-105 min and thereafter achieved plasma activity equivalent to the intravenously administered tracer. Eighty percent or greater of the 35S dose was recovered in the 24-h urine, following either intravenous or oral administration. The mean extracellular fluid space demonstrated less than 9% mean difference between routes of administration. It is concluded that 35S is completely absorbed at tracer doses, and may be administered orally as a reliable substitute for intravenously administered 35S for measuring extracellular fluid space.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
0021-8987
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
40
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
648-50
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:931888-Administration, Oral,
pubmed-meshheading:931888-Extracellular Space,
pubmed-meshheading:931888-Humans,
pubmed-meshheading:931888-Injections, Intravenous,
pubmed-meshheading:931888-Sulfates,
pubmed-meshheading:931888-Sulfur Radioisotopes,
pubmed-meshheading:931888-Time Factors
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pubmed:year |
1976
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pubmed:articleTitle |
Oral administration of radioactive sulfate to measure extracellular fluid space in man.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
|