Linked Life Data

9315208

Source:http://linkedlifedata.com/resource/pubmed/id/9315208

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1997-11-4
pubmed:abstractText
The aim of this study was to evaluate the performance of a new therapeutic ultrasound device for accelerating thrombolysis by urokinase. Artificial thrombi were produced in vitro by Chandler's loop method. Urokinase (240 IU) was added to the artificial thrombi (n = 5) before exposure to ultrasound with the new catheter-delivered device. Ultrasound (1.3 MHz) was applied with an intensity of 0.3 W/cm2 for 60 s. The degree of fibrinolysis was obtained by measurement of thrombus weight and calculated as percentages. Fibrinolysis was compared between control thrombus groups (n = 5) treated with urokinase alone or with ultrasound alone (analysis of variance, P < 0.05). Ultrasound plus urokinase (33.1 +/- 6.1% [mean +/- standard deviation]) was significantly different urokinase alone (12.3 +/- 2.4%) after 15 min of incubation. Ultrasound alone resulted in no fibrinolysis (0.9 +/- 2.5%). Ultrasound energy from the catheter-based device was sufficient to induce acceleration of fibrinolysis with urokinase.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0278-4297
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
529-35
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Prototype therapeutic ultrasound emitting catheter for accelerating thrombolysis.
pubmed:affiliation
First Department of Internal Medicine, Fukuoka University School of Medicine, Japan.
pubmed:publicationType
Journal Article