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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
1997-10-21
|
| pubmed:abstractText |
Helicobacter pylori infection has been implicated in the development of chronic active gastritis and gastric neoplasms (ie, mucosa-associated lymphoid tumors and adenocarcinoma). The potential association between esophageal H pylori infection with Barrett's esophagus-associated adenocarcinoma has not been previously studied. Nineteen cases of adenocarcinoma arising in Barrett's esophagus were examined for the presence of H pylori. Barrett's esophagus was defined by the presence of metaplastic specialized-type epithelium (gastric-type epithelium with goblet cell metaplasia) in the distal esophagus. To detect the presence of H pylori, 5-microm sections, from several tissue blocks in each case, were stained with routine hematoxylin-eosin, modified Giemsa, and an antibody directed against H pylori (Dako a/s, Denmark, Lot # 111061). Stained sections were examined independently by two pathologists. All three staining methods failed to show H pylori in any of the cases examined. Sections of Barrett's esophagus (with and without dysplasia), adenocarcinoma, and stomach (when available) were uniformly negative for the presence of H pylori. We conclude that neither gastric nor esophageal infection with H pylori is a requisite for the development of adenocarcinoma in Barrett's esophagus. Moreover, it is unlikely that a significant association between H pylori infection and Barrett's-associated adenocarcinoma exists.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0046-8177
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
28
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1007-9
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:9308723-Adenocarcinoma,
pubmed-meshheading:9308723-Adult,
pubmed-meshheading:9308723-Aged,
pubmed-meshheading:9308723-Barrett Esophagus,
pubmed-meshheading:9308723-Helicobacter Infections,
pubmed-meshheading:9308723-Helicobacter pylori,
pubmed-meshheading:9308723-Humans,
pubmed-meshheading:9308723-Male,
pubmed-meshheading:9308723-Middle Aged
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Helicobacter pylori infection and adenocarcinoma arising in Barrett's esophagus.
|
| pubmed:affiliation |
Department of Pathology, Rhode Island Hospital and Brown University School of Medicine, Providence 02903, USA.
|
| pubmed:publicationType |
Journal Article
|