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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6648
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pubmed:dateCreated |
1997-9-30
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pubmed:abstractText |
A variety of extracellular signals are transduced across the cell membrane by the enzyme phosphoinositide-specific phospholipase C-beta (PLC-beta) coupled with guanine-nucleotide-binding G proteins. There are four isoenzymes of PLC-beta, beta1-beta4, but their functions in vivo are not known. Here we investigate the role of PLC-beta1 and PLC-beta4 in the brain by generating null mutations in mice: we found that PLCbeta1-/- mice developed epilepsy and PLCbeta4-/- mice showed ataxia. We determined the molecular basis of these phenotypes and show that PLC-beta1 is involved in signal transduction in the cerebral cortex and hippocampus by coupling predominantly to the muscarinic acetylcholine receptor, whereas PLC-beta4 works through the metabotropic glutamate receptor in the cerebellum, illustrating how PLC-beta isoenzymes are used to generate different functions in the brain.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1-(3-chlorophenyl)piperazine,
http://linkedlifedata.com/resource/pubmed/chemical/1-amino-1,3-dicarboxycyclopentane,
http://linkedlifedata.com/resource/pubmed/chemical/Carbachol,
http://linkedlifedata.com/resource/pubmed/chemical/Cycloleucine,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Muscarinic Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositols,
http://linkedlifedata.com/resource/pubmed/chemical/Phospholipase C beta,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Plcb1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Plcb4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Metabotropic Glutamate,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Muscarinic,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Receptor Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Type C Phospholipases
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0028-0836
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
389
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
290-3
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:9305844-Animals,
pubmed-meshheading:9305844-Ataxia,
pubmed-meshheading:9305844-Binding Sites,
pubmed-meshheading:9305844-Brain,
pubmed-meshheading:9305844-Carbachol,
pubmed-meshheading:9305844-Cerebellum,
pubmed-meshheading:9305844-Cycloleucine,
pubmed-meshheading:9305844-Epilepsy,
pubmed-meshheading:9305844-Hippocampus,
pubmed-meshheading:9305844-Isoenzymes,
pubmed-meshheading:9305844-Mice,
pubmed-meshheading:9305844-Mice, Knockout,
pubmed-meshheading:9305844-Muscarinic Agonists,
pubmed-meshheading:9305844-Mutagenesis,
pubmed-meshheading:9305844-Phosphatidylinositols,
pubmed-meshheading:9305844-Phospholipase C beta,
pubmed-meshheading:9305844-Piperazines,
pubmed-meshheading:9305844-Receptors, Metabotropic Glutamate,
pubmed-meshheading:9305844-Receptors, Muscarinic,
pubmed-meshheading:9305844-Serotonin Receptor Agonists,
pubmed-meshheading:9305844-Signal Transduction,
pubmed-meshheading:9305844-Type C Phospholipases
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pubmed:year |
1997
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pubmed:articleTitle |
Phospholipase C isozymes selectively couple to specific neurotransmitter receptors.
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pubmed:affiliation |
Department of Life Science, Pohang University of Science and Technology, Republic of Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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