|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
1997-9-19
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|
pubmed:abstractText |
The interferon-inducing and antiviral activities of high-molecular interferon inducers larifan and rifastin and of gene engineering human alpha 2-interferon were studied in monkeys infected with smallpox. These agents appreciably prolonged the life span of infected monkeys. For green monkeys the drug efficacies were as follows: larifan protected 50%, rifastin 86%, and realderon 50% (if used for treatment) and 80% (if used for urgent prophylaxis) of animals from death; for Papio hamadryas the efficacy of urgent prophylaxis was 60%. Interferon accumulated in the serum as early as during the first hours after injection of interferon inducers, the peak concentrations being observed after 3-6 h; for realderone the peak was observed after 9 h. The levels of interferon induction with larifan and rifastin were virtually the same.
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|
pubmed:language |
rus
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0507-4088
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
42
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
186-8
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|
pubmed:dateRevised |
2011-11-17
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|
pubmed:meshHeading |
pubmed-meshheading:9304302-Animals,
pubmed-meshheading:9304302-Antiviral Agents,
pubmed-meshheading:9304302-Cercopithecus aethiops,
pubmed-meshheading:9304302-Chick Embryo,
pubmed-meshheading:9304302-Humans,
pubmed-meshheading:9304302-Interferon Inducers,
pubmed-meshheading:9304302-Interferon Type I,
pubmed-meshheading:9304302-Organic Chemicals,
pubmed-meshheading:9304302-Papio,
pubmed-meshheading:9304302-Recombinant Proteins,
pubmed-meshheading:9304302-Smallpox
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|
pubmed:articleTitle |
[Study of the effectiveness of recombinant alpha2-interferon and its inducers in primates with orthopoxvirus infection].
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|
pubmed:publicationType |
Journal Article,
English Abstract
|
