Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1997-10-8
|
| pubmed:abstractText |
The newly cloned and characterized hepatitis GB virus-C (HGBV-C), which is the same virus as the independently discovered hepatitis G virus, has a global distribution, is transmitted parenterally, and causes chronic viremia. The pathological consequences of infection with HGBV-C are uncertain, and its hepatocarcinogenic potential is unknown. We used a case-control format to compare the prevalence of HGBV-C infection in 167 southern African blacks with hepatocellular carcinoma (HCC) and 167 race-, age-, and sex-matched hospital-based control subjects, and to test for possible interactive effects between this virus and hepatitis B and C viruses in the development of the tumor. The presence of HGBV-C ribonucleic acid was detected in serum samples by reverse transcription, amplification of the resulting complementary deoxyribonucleic acid by the polymerase chain reaction (PCR), and Southern hybridization using a probe from the NS3/helicase region of the genome. Serum samples were also tested for the presence of hepatitis B virus surface antigen, antibodies to hepatitis C virus, and hepatitis C virus ribonucleic acid. Individuals infected with HGBV-C did not have an increased relative risk of developing HCC (relative risk 0.9; 95% confidence limits 0.5, 1.7). Moreover, co-infection with HGBV-C did not further increase the risk of tumor development in patients who were chronically infected with hepatitis B and/or C viruses. HGBV-C is unrelated to hepatocellular carcinoma development in black Africans.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0270-9139
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
26
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
740-2
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:9303506-African Americans,
pubmed-meshheading:9303506-African Continental Ancestry Group,
pubmed-meshheading:9303506-Carcinoma, Hepatocellular,
pubmed-meshheading:9303506-Case-Control Studies,
pubmed-meshheading:9303506-Confidence Intervals,
pubmed-meshheading:9303506-DNA, Viral,
pubmed-meshheading:9303506-Ethnic Groups,
pubmed-meshheading:9303506-Female,
pubmed-meshheading:9303506-Flaviviridae,
pubmed-meshheading:9303506-Hepatitis, Viral, Human,
pubmed-meshheading:9303506-Hepatitis B,
pubmed-meshheading:9303506-Hepatitis C,
pubmed-meshheading:9303506-Humans,
pubmed-meshheading:9303506-Liver Neoplasms,
pubmed-meshheading:9303506-Male,
pubmed-meshheading:9303506-Polymerase Chain Reaction,
pubmed-meshheading:9303506-RNA, Viral,
pubmed-meshheading:9303506-Risk Assessment,
pubmed-meshheading:9303506-Risk Factors,
pubmed-meshheading:9303506-South Africa
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Does hepatitis GB virus-C infection cause hepatocellular carcinoma in black Africans?
|
| pubmed:affiliation |
Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|