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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1997-10-10
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pubmed:abstractText |
To evaluate the role of Th2-type cytokines in the nasal mucosa which has been repeatedly exposed to antigen, an immunohistological study for IL-4, IL-5 and IL-6 was performed in patients with perennial allergic rhinitis and non allergic rhinosinusitis. The numbers of immunoreactive (ir)-IL-4, ir-IL-5 and ir-IL-6-positive cells were significantly higher in allergic mucosa than in nonallergic mucosa. In allergic mucosa, the numbers of these ir-cytokine-positive cells were significantly higher in the antigen-challenged site than in the control site. When the patients were divided into an early group (4-6 h after challenge) and a later group (15-25 h after challenge), only the change of ir-IL-4-positive cells was remarkable in the former group, whereas those of the ir-IL-4, ir-IL-5 and ir-IL-6-positive cells were significant in the latter group. These results suggest that antigen-induced upregulation of IL-4, IL-5 and IL-6 is important in the pathogenesis of perennial allergic rhinitis.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1018-2438
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
114
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
81-5
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9303335-Administration, Intranasal,
pubmed-meshheading:9303335-Adolescent,
pubmed-meshheading:9303335-Adult,
pubmed-meshheading:9303335-Aged,
pubmed-meshheading:9303335-Antigens,
pubmed-meshheading:9303335-Cell Count,
pubmed-meshheading:9303335-Humans,
pubmed-meshheading:9303335-Immunohistochemistry,
pubmed-meshheading:9303335-Interleukin-4,
pubmed-meshheading:9303335-Interleukin-5,
pubmed-meshheading:9303335-Interleukin-6,
pubmed-meshheading:9303335-Kinetics,
pubmed-meshheading:9303335-Middle Aged,
pubmed-meshheading:9303335-Nasal Mucosa,
pubmed-meshheading:9303335-Nasal Provocation Tests,
pubmed-meshheading:9303335-Rhinitis,
pubmed-meshheading:9303335-Rhinitis, Allergic, Perennial,
pubmed-meshheading:9303335-Sinusitis,
pubmed-meshheading:9303335-Th2 Cells
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pubmed:year |
1997
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pubmed:articleTitle |
Topical antigen provocation increases the number of immunoreactive IL-4-, IL-5- and IL-6-positive cells in the nasal mucosa of patients with perennial allergic rhinitis.
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pubmed:affiliation |
Department of Otolaryngology, Sapporo Medical University, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study
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