Linked Life Data

9296891

Source:http://linkedlifedata.com/resource/pubmed/id/9296891

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1997-9-17
pubmed:abstractText
Recognition of early microcirculatory disturbances in feet of diabetics may facilitate the pathogenic interpretation of the diabetic foot syndrome, selection of the patients at risk of developing clinical problems and serve as the base for designing the preventive measures. This could be particularly true in diabetics with peripheral neuropathy. Therefore the study aimed at the assessment of functional parameters of the foot microcirculation in IDDM patients presenting signs of peripheral neuropathy but without any symptoms of the diabetic foot syndrome was undertaken. For comparison 20 IDDM subjects with the signs of peripheral neuropathy and 10 IDDM subjects without this complication were studied both clinically and metabolically. All of them underwent the examination of microcirculation of the feet with the use of Laser Doppler Flowmeter. The parameters measured were: resting blood flow, post-occlusive, hyperemic response, flow change after heating to 44 degrees C and the flow on dependency. In IDDM subjects with peripheral neuropathy the following functional microcirculatory abnormalities were found: delay and decrease in post-occlusive, hyperemic response (4.5 +/- 1.8 s in neuropathic vs 0.5 +/- 2.4 s in non-neuropathic IDDM patients), decrease of the peak flow (36 +/- 7.0 PU in non neuropathic vs 18 +/- 5.0 PU in neuropathic IDDM patients) and also impairment of the response of the skin flow to focal heating peak flow at 44 degrees C (48 +/- 7.0 PU vs 12 +/- 3.0 PU in non neuropathic IDDM patients). Also the venoarteriolar reflex measured as the ratio of resting to standing flow in the feet skin was significantly decreased (80% in non-neuropathic versus 35% in neuropathic IDDM patients). Conclusion: Laser Doppler Flowmetry discovers the very early functional abnormalities in the microcirculation of the skin in the feet of IDDM with peripheral neuropathy, when none of the typical symptoms of the diabetic foot syndrome is present. It points to the significance of the relation between neuropathic and microcirculatory disturbances in the early pathogenesis of diabetic foot syndrome.
pubmed:language
pol
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1426-9686
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
18-20
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
[Microcirculatory evaluation of the early diabetic foot syndrome using laser doppler].
pubmed:affiliation
Kliniki Chorób Wewnetrznych i Diabetologii Akademii Medycznej w Warszawie.
pubmed:publicationType
Journal Article, Clinical Trial, English Abstract, Controlled Clinical Trial