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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1997-9-25
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pubmed:databankReference |
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pubmed:abstractText |
Human GATA-6 has been cloned from foetal heart by a combination of PCR-based methods and cDNA library screening. The 3.8 kbp cDNA has a coding sequence of 1347 bp the 449 aa protein is virtually identical in the two zinc-finger binding domains to other human GATA sequences, but varies considerably in the amino and carboxy terminal regions. The sequence shows greatest similarity to GATA-6-like sequences from rat, mouse, chicken and Xenopus. Northern analysis and in situ hybridisation show that GATA-6 is expressed at high levels in human adult and foetal heart as well as in gut derivatives. It is postulated that GATA-6, in concert with GATA-4, plays a crucial role in the regulation of cardiac differentiation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0006-3002
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
1353
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
98-102
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9294001-Amino Acid Sequence,
pubmed-meshheading:9294001-Base Sequence,
pubmed-meshheading:9294001-Cloning, Molecular,
pubmed-meshheading:9294001-DNA, Complementary,
pubmed-meshheading:9294001-DNA-Binding Proteins,
pubmed-meshheading:9294001-Digestive System,
pubmed-meshheading:9294001-Fetus,
pubmed-meshheading:9294001-GATA6 Transcription Factor,
pubmed-meshheading:9294001-Gene Expression,
pubmed-meshheading:9294001-Gene Library,
pubmed-meshheading:9294001-Humans,
pubmed-meshheading:9294001-In Situ Hybridization,
pubmed-meshheading:9294001-Molecular Sequence Data,
pubmed-meshheading:9294001-Myocardium,
pubmed-meshheading:9294001-Transcription Factors
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pubmed:year |
1997
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pubmed:articleTitle |
Molecular cloning of human GATA-6 DNA binding protein: high levels of expression in heart and gut.
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pubmed:affiliation |
Department of Molecular Medicine, Institute of Liver Studies, King's College School of Medicine and Dentistry, Camberwell, London, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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