Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
1997-10-6
|
| pubmed:abstractText |
Negative signaling in B cells is initiated by co-crosslinking of the antigen receptor and the Fcy receptor, resulting in cessation of B-cell signaling events and, in turn, inhibiting B-cell proliferation and antibody secretion. Here, a competitive role is proposed for SHIP in blocking the interaction of Shc with the Grb2-Sos complex of proteins that lead to Ras activation in B cells.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0167-5699
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
18
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
424-7
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:9293157-Allergy and Immunology,
pubmed-meshheading:9293157-Animals,
pubmed-meshheading:9293157-B-Lymphocytes,
pubmed-meshheading:9293157-Humans,
pubmed-meshheading:9293157-Models, Biological,
pubmed-meshheading:9293157-Phosphoric Monoester Hydrolases,
pubmed-meshheading:9293157-Signal Transduction,
pubmed-meshheading:9293157-ras Proteins,
pubmed-meshheading:9293157-src Homology Domains
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Negative signaling in B cells: SHIP Grbs Shc.
|
| pubmed:affiliation |
Ohio State University, Dept of Microbiology, Columbus 43210, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Review
|