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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1997-10-2
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pubmed:abstractText |
Bactericidal permeability increasing protein (BPI) binds to and neutralizes lipopolysaccharide (LPS, endotoxin). Small synthetic peptides based on the amino acid sequence of the LPS binding domain of BPI neutralize LPS, albeit inefficiently. Although the LPS binding domain of native BPI possesses a beta-turn secondary structure, this structure is not present in small derivative peptides. The purpose of this study was to determine whether the addition of a beta-turn to a BPI-derived peptide is associated with more potent endotoxin antagonism.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0039-6060
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
122
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
380-5
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9288144-Amino Acid Sequence,
pubmed-meshheading:9288144-Animals,
pubmed-meshheading:9288144-Antimicrobial Cationic Peptides,
pubmed-meshheading:9288144-Binding Sites,
pubmed-meshheading:9288144-Blood Bactericidal Activity,
pubmed-meshheading:9288144-Blood Proteins,
pubmed-meshheading:9288144-Cell Line,
pubmed-meshheading:9288144-Endotoxemia,
pubmed-meshheading:9288144-Endotoxins,
pubmed-meshheading:9288144-Escherichia coli,
pubmed-meshheading:9288144-Humans,
pubmed-meshheading:9288144-Lipopolysaccharides,
pubmed-meshheading:9288144-Membrane Proteins,
pubmed-meshheading:9288144-Mice,
pubmed-meshheading:9288144-Molecular Sequence Data,
pubmed-meshheading:9288144-Peptide Fragments,
pubmed-meshheading:9288144-Pseudomonas aeruginosa,
pubmed-meshheading:9288144-Tumor Necrosis Factor-alpha
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pubmed:year |
1997
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pubmed:articleTitle |
Design of a potent novel endotoxin antagonist.
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pubmed:affiliation |
Department of Surgery, University of Minnesota, Minneapolis 55455, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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