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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5332
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pubmed:dateCreated |
1997-9-29
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pubmed:abstractText |
Gangliosides participate in development and tissue differentiation. Cross-linking of the apoptosis-inducing CD95 protein (also called Fas or APO-1) in lymphoid and myeloid tumor cells triggered GD3 ganglioside synthesis and transient accumulation. CD95-induced GD3 accumulation depended on integral receptor "death domains" and on activation of a family of cysteine proteases called caspases. Cell-permeating ceramides, which are potent inducers of apoptosis, also triggered GD3 synthesis. GD3 disrupted mitochondrial transmembrane potential (DeltaPsim), and induced apoptosis, in a caspase-independent fashion. Transient overexpression of the GD3 synthase gene directly triggered apoptosis. Pharmacological inhibition of GD3 synthesis and exposure to GD3 synthase antisense oligodeoxynucleotides prevented CD95-induced apoptosis. Thus, GD3 ganglioside mediates the propagation of CD95-generated apoptotic signals in hematopoietic cells.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD95,
http://linkedlifedata.com/resource/pubmed/chemical/Ceramides,
http://linkedlifedata.com/resource/pubmed/chemical/Cysteine Endopeptidases,
http://linkedlifedata.com/resource/pubmed/chemical/Cysteine Proteinase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Gangliosides,
http://linkedlifedata.com/resource/pubmed/chemical/Morpholines,
http://linkedlifedata.com/resource/pubmed/chemical/Oligonucleotides, Antisense,
http://linkedlifedata.com/resource/pubmed/chemical/RV 538,
http://linkedlifedata.com/resource/pubmed/chemical/Sialyltransferases,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-N-acetylneuraminate...,
http://linkedlifedata.com/resource/pubmed/chemical/ganglioside, GD3
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
12
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pubmed:volume |
277
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1652-5
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pubmed:dateRevised |
2007-3-19
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pubmed:meshHeading |
pubmed-meshheading:9287216-Antigens, CD95,
pubmed-meshheading:9287216-Apoptosis,
pubmed-meshheading:9287216-Ceramides,
pubmed-meshheading:9287216-Cysteine Endopeptidases,
pubmed-meshheading:9287216-Cysteine Proteinase Inhibitors,
pubmed-meshheading:9287216-Enzyme Inhibitors,
pubmed-meshheading:9287216-Gangliosides,
pubmed-meshheading:9287216-Golgi Apparatus,
pubmed-meshheading:9287216-Humans,
pubmed-meshheading:9287216-Membrane Potentials,
pubmed-meshheading:9287216-Mitochondria,
pubmed-meshheading:9287216-Morpholines,
pubmed-meshheading:9287216-Oligonucleotides, Antisense,
pubmed-meshheading:9287216-Sialyltransferases,
pubmed-meshheading:9287216-Signal Transduction,
pubmed-meshheading:9287216-Transfection,
pubmed-meshheading:9287216-Tumor Cells, Cultured
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pubmed:year |
1997
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pubmed:articleTitle |
Requirement for GD3 ganglioside in CD95- and ceramide-induced apoptosis.
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pubmed:affiliation |
Department of Experimental Medicine and Biochemical Sciences, University of Rome "Tor Vergata," 00133 Rome, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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