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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
1997-10-17
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pubmed:abstractText |
The Elav-like proteins are specific mRNA binding proteins which are required for cellular differentiation. They contain three characteristic RNP2/RNP1-type RNA binding motifs. Previously we have shown that the first and second RNA binding domains bind to AU-rich elements in the 3'-UTR of mRNA. In this paper we show that the Elav-like proteins exhibit poly(A) binding activity. This activity is distinct from poly(A) binding activities that have been previously described. The Elav-like proteins specifically bind to long chain poly(A) tails. We have shown that the third RNA binding domain encompasses this poly(A) binding activity. Using poly(A)-Sepharose beads in a 'sandwich' assay we have shown that the Elav-like proteins can bind simultaneously to the AU-rich element and to the poly(A) tail.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9278474-1655278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9278474-1756732,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9278474-1901943,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9278474-19970364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9278474-2984600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9278474-3144044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9278474-3194021,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9278474-3313012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9278474-3488815,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9278474-6347247,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9278474-7511893,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9278474-7517436,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9278474-7547471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9278474-7565413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9278474-7753842,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9278474-7898713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9278474-7908267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9278474-7972035,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9278474-8158249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9278474-8428968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9278474-8497264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9278474-8535975,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9278474-8582616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9278474-8586967,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9278474-8626503,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9278474-8626712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9278474-9001249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9278474-9016658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9278474-9045688,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9278474-9155038
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0305-1048
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3564-9
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pubmed:dateRevised |
2010-9-13
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pubmed:meshHeading |
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pubmed:year |
1997
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pubmed:articleTitle |
The Elav-like proteins bind to AU-rich elements and to the poly(A) tail of mRNA.
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pubmed:affiliation |
Program in Molecular Pharmacology and Therapeutics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021 USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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