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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
1997-10-1
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pubmed:databankReference |
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pubmed:abstractText |
Dendritic spines receive the vast majority of excitatory synaptic contacts in the mammalian brain and are presumed to contain machinery for the integration of various signal transduction pathways. Protein phosphatase 1 (PP1) is greatly enriched in dendritic spines and has been implicated in both the regulation of ionic conductances and long-term synaptic plasticity. The molecular mechanism whereby PP1 is localized to spines is unknown. We have now characterized a novel protein that forms a complex with the catalytic subunit of PP1 and is a potent modulator of PP1 enzymatic activity in vitro. Within the brain this protein displays a remarkably distinct localization to the heads of dendritic spines and has therefore been named spinophilin. Spinophilin has the properties expected of a scaffolding protein localized to the cell membrane and contains a single consensus sequence in PSD95/DLG/zo-1, which implies cross-linking of PP1 to transmembrane protein complexes. We propose that spinophilin represents a novel targeting subunit for PP1, which directs the enzyme to those substrates in the dendritic spine compartment, e.g., neurotransmitter receptors, which mediate the regulation of synaptic function by PP1.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9275233-1631061,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9275233-2031185,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9275233-2164027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9275233-2231712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9275233-2547163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9275233-2842604,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9275233-7515479,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9275233-7531987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9275233-7542990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9275233-7724573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9275233-7751917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9275233-7891112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9275233-8133283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9275233-8190644,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9275233-8210179,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9275233-8392229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9275233-8625403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9275233-8674113,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9275233-8974395
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
2
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pubmed:volume |
94
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
9956-61
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9275233-Amino Acid Sequence,
pubmed-meshheading:9275233-Animals,
pubmed-meshheading:9275233-Cloning, Molecular,
pubmed-meshheading:9275233-Dendrites,
pubmed-meshheading:9275233-Hippocampus,
pubmed-meshheading:9275233-Microfilament Proteins,
pubmed-meshheading:9275233-Molecular Sequence Data,
pubmed-meshheading:9275233-Nerve Tissue Proteins,
pubmed-meshheading:9275233-Phosphoprotein Phosphatases,
pubmed-meshheading:9275233-Protein Binding,
pubmed-meshheading:9275233-Protein Phosphatase 1,
pubmed-meshheading:9275233-Rats,
pubmed-meshheading:9275233-Sequence Alignment,
pubmed-meshheading:9275233-Thalamus
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pubmed:year |
1997
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pubmed:articleTitle |
Spinophilin, a novel protein phosphatase 1 binding protein localized to dendritic spines.
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pubmed:affiliation |
Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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