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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1997-9-9
|
| pubmed:abstractText |
Between June 1986 and November 1994, 22 previously transfused patients with severe aplastic anemia (SAA) were treated with high-dose cyclophosphamide (CY) (50 mg/kg over 4 consecutive days) and 7 Gy total lymphoid irradiation (TLI) in two fractions before allogeneic bone marrow transplantation (BMT) from HLA-identical sibling. Graft-versus-host-disease (GVHD) prophylaxis included the combination of methotrexate and cyclosporine A in all cases. Actuarial survival at 5 years is 73 +/- 9 per cent for the entire group and 86 +/- 13 per cent for the seven patients < or = 18 years. The incidence of graft failure was 0 per cent, and of acute GVHD and chronic GVHD was 31.5 per cent and 24 per cent respectively. Prolonged interval from diagnosis to BMT adversely influenced survival (P = 0.03). No hypothyroidism or secondary malignancies have been documented in this series. Our findings indicate that survival with CY-TLI is comparable to that obtained using preparative regimens without radiation. The changing role of radiotherapy in pretransplant immunosuppression for SAA is discussed.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0278-0232
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
14
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
165-72
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:9267462-Adolescent,
pubmed-meshheading:9267462-Adult,
pubmed-meshheading:9267462-Anemia, Aplastic,
pubmed-meshheading:9267462-Bone Marrow Purging,
pubmed-meshheading:9267462-Bone Marrow Transplantation,
pubmed-meshheading:9267462-Child,
pubmed-meshheading:9267462-Cyclophosphamide,
pubmed-meshheading:9267462-Cyclosporine,
pubmed-meshheading:9267462-Drug Therapy, Combination,
pubmed-meshheading:9267462-Female,
pubmed-meshheading:9267462-Follow-Up Studies,
pubmed-meshheading:9267462-Graft vs Host Disease,
pubmed-meshheading:9267462-Humans,
pubmed-meshheading:9267462-Immunosuppressive Agents,
pubmed-meshheading:9267462-Lymphoid Tissue,
pubmed-meshheading:9267462-Male,
pubmed-meshheading:9267462-Methotrexate,
pubmed-meshheading:9267462-Middle Aged,
pubmed-meshheading:9267462-Risk Factors,
pubmed-meshheading:9267462-Survival Rate,
pubmed-meshheading:9267462-Transplantation Conditioning
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Successful bone marrow transplantation in sensitized aplastic anemia patients using total lymphoid irradiation for conditioning: long-term follow-up.
|
| pubmed:affiliation |
Department of Radiation Oncology, Hospital Universitario de la Princesa, Madrid, Spain.
|
| pubmed:publicationType |
Journal Article
|