Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8 Pt 1
|
| pubmed:dateCreated |
1997-9-11
|
| pubmed:abstractText |
We used inductively coupled plasma-atomic emission spectroscopy to measure serum iodine to determine plasma clearance of iohexol, an iodinated radiographic contrast agent. We determined I at 178.276 nm on the phosphorus 178.287 nm channel of the polychromator by utilization of spectrum shifter offset software, while correcting for P with the sequential P 214.914 nm emission line. Determination of I on the polychromator provided excellent precision in the measurement of serum I, even though the interelement correction of P was done with a sequential P line. Total imprecision (CV) (n = 13) was 16% (at 13.7 mg/L I), 8.6% (28.7 mg/L), 3.6% (59.0 mg/L), 2.6% (120.5 mg/L), 1.7% (237.8 mg/L), 1.2% (478.7 mg/L), and 1.8% (597 mg/L). The linear range was 15 to 600 mg/L. Iohexol added to serum (mg/L I) and recoveries (%) were 15 (91.3%), 30 (95.7%), 60 (98.3%), 120 (100.4%), 240 (99.1%), 480 (99.7%), and 600 (99.5%). Studies on dogs and cats administered a single intravenous injection of iohexol indicated that a dose of 300 mg I/kg body weight was sufficient for measurement of glomerular filtration rate by using a single compartment model for plasma clearance with three samples drawn 3 to 7 h after treatment. With this protocol, correlation coefficients were > 0.99 on the beta phase of the plasma disappearance curve.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0009-9147
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
43
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1429-35
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:9267324-Animals,
pubmed-meshheading:9267324-Cats,
pubmed-meshheading:9267324-Contrast Media,
pubmed-meshheading:9267324-Dogs,
pubmed-meshheading:9267324-Female,
pubmed-meshheading:9267324-Glomerular Filtration Rate,
pubmed-meshheading:9267324-Iodine,
pubmed-meshheading:9267324-Iohexol,
pubmed-meshheading:9267324-Male,
pubmed-meshheading:9267324-Reproducibility of Results,
pubmed-meshheading:9267324-Sensitivity and Specificity,
pubmed-meshheading:9267324-Spectrum Analysis
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Measurement of serum iohexol by determination of iodine with inductively coupled plasma-atomic emission spectroscopy.
|
| pubmed:affiliation |
Department of Pharmacology and Toxicology, College of Veterinary Medicine, Michigan State University, E. Lansing 46824, USA. braselton@ahdlms.cvm.msu.edu
|
| pubmed:publicationType |
Journal Article
|