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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1997-9-17
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pubmed:abstractText |
The chemokine receptor CCR5 acts as an essential cofactor for cell entry by macrophage-tropic human immunodeficiency virus type 1 (HIV-1) strains, whereas CXCR4 acts as an essential cofactor for T-cell-line-adapted strains. We demonstrated that the specific amino acids in the V3 loop of the HIV-1 envelope protein that determine cellular tropism also regulate chemokine coreceptor preference for cell entry by the virus. Further, a strong correlation was found between HIV-1 strains classified as syncytium inducing in standard assays and those using CXCR4 as a coreceptor. These data support the hypothesis that progressive adaptation to additional coreceptors is a key molecular basis for HIV-1 phenotypic evolution in vivo.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9261451-1404602,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9261451-1404617,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9261451-1560543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9261451-1727490,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9261451-1738194,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9261451-1905842,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9261451-1920616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9261451-2475780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9261451-2564898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9261451-2840658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9261451-3016298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9261451-3130494,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9261451-7483281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9261451-7545945,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9261451-7592573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9261451-7742038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9261451-7909549,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9261451-8139036,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9261451-8350416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9261451-8497073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9261451-8502996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9261451-8568295,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9261451-8595502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9261451-8629022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9261451-8649511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9261451-8649512,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9261451-8658158,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9261451-8658171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9261451-8674119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9261451-8674120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9261451-8898753,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9261451-8943208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9261451-8971043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9261451-8995695,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9261451-8995702,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9261451-9020356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9261451-9094670
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Envelope Protein gp120,
http://linkedlifedata.com/resource/pubmed/chemical/HIV envelope protein gp120 (305-321),
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR5,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CXCR4,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytokine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, HIV
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
71
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7136-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9261451-Amino Acid Sequence,
pubmed-meshheading:9261451-Animals,
pubmed-meshheading:9261451-Antigens, CD4,
pubmed-meshheading:9261451-COS Cells,
pubmed-meshheading:9261451-HIV Envelope Protein gp120,
pubmed-meshheading:9261451-HIV-1,
pubmed-meshheading:9261451-HeLa Cells,
pubmed-meshheading:9261451-Humans,
pubmed-meshheading:9261451-Membrane Proteins,
pubmed-meshheading:9261451-Molecular Sequence Data,
pubmed-meshheading:9261451-Peptide Fragments,
pubmed-meshheading:9261451-Receptors, CCR5,
pubmed-meshheading:9261451-Receptors, CXCR4,
pubmed-meshheading:9261451-Receptors, Cytokine,
pubmed-meshheading:9261451-Receptors, HIV,
pubmed-meshheading:9261451-Structure-Activity Relationship
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pubmed:year |
1997
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pubmed:articleTitle |
Selective employment of chemokine receptors as human immunodeficiency virus type 1 coreceptors determined by individual amino acids within the envelope V3 loop.
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pubmed:affiliation |
Gladstone Institute of Virology and Immunology, San Francisco, California, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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