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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1997-8-26
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pubmed:abstractText |
After intrahepatic transplantation into livers of adult syngeneic German-strain Fischer 344 rats that are deficient for the bile canalicular enzyme dipeptidyl peptidase IV (DPP-IV), cultured WB-F344 rat liver epithelial cells (without exogenous marker genes) integrate into hepatic plates and differentiate into hepatocyte-like cells that are morphologically and functionally indistinguishable from mature hepatocytes. In this model system, the differentiated progeny of transplanted WB-F344 cells are identified among the DPP-IV-negative host hepatocytes by their expression of bile canalicular DPP-IV enzyme activity. DPP-IV-positive hepatocyte-like cells also expressed other markers of hepatocytic differentiation, including albumin, transferrin, and alpha-1-antitrypsin, suggesting that the progeny of transplanted WB-F344 cells express a complete hepatocyte differentiation program. These results complement our previous studies indicating WB-F344 cells can serve as stem-like precursor cells for differentiated hepatocytes and strengthen the suggestion that WB-F344 rat liver epithelial cells represent the cultured counterpart of liver stem-like hepatocyte progenitor cells present in the normal adult rat liver.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9250149-13410831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9250149-1705112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9250149-1710229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9250149-1716045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9250149-1717143,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9250149-1972662,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9250149-2022751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9250149-2111209,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9250149-2456278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9250149-2466557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9250149-2470253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9250149-2619882,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9250149-2665241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9250149-2862991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9250149-2883023,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9250149-3031986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9250149-3099292,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9250149-3664968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9250149-3970142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9250149-429202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9250149-451621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9250149-6468534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9250149-6873976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9250149-6991912,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9250149-7013608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9250149-7504886,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9250149-7557877,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9250149-7597042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9250149-7694303,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9250149-7962128,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9250149-8234370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9250149-8494041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9250149-8613008,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9250149-8816880,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9250149-9021943
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0002-9440
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
151
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
353-9
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:9250149-Animals,
pubmed-meshheading:9250149-Cell Differentiation,
pubmed-meshheading:9250149-Cell Transplantation,
pubmed-meshheading:9250149-Dipeptidyl Peptidase 4,
pubmed-meshheading:9250149-Epithelium,
pubmed-meshheading:9250149-Immunohistochemistry,
pubmed-meshheading:9250149-Liver,
pubmed-meshheading:9250149-Rats,
pubmed-meshheading:9250149-Rats, Inbred F344,
pubmed-meshheading:9250149-Stem Cells
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pubmed:year |
1997
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pubmed:articleTitle |
Evaluation of the differentiation potential of WB-F344 rat liver epithelial stem-like cells in vivo. Differentiation to hepatocytes after transplantation into dipeptidylpeptidase-IV-deficient rat liver.
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pubmed:affiliation |
Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill 27599, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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