Linked Life Data

924995

Source:http://linkedlifedata.com/resource/pubmed/id/924995

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
23
pubmed:dateCreated
1978-1-27
pubmed:abstractText
The role of the carbohydrate moiety in influencing the survival time of human lymphoblastoid interferon in the rat circulation was monitored at varying time intervals after intravenous injection. The serum survival time of native interferon was drastically reduced by prior enzymatic cleavage of the terminal sialic acid residues to yield the galactose-terminal product, asialo-interferon. This phenomenon was completely reversed by further extensive digestion with a mixture of glycosidases which effectively removed over 85% of the total carbohydrate residues. These results suggest that the intact carbohydrate structure is neither essential for normal circulation time in vivo nor for biologic activity in vitro.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0021-9258
pubmed:author
pubmed:issnType
Print
pubmed:day
10
pubmed:volume
252
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
8336-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1977
pubmed:articleTitle
Role of the carbohydrate moiety in determining the survival of interferon in the circulation.
pubmed:publicationType
Journal Article