Linked Life Data

9249202

Source:http://linkedlifedata.com/resource/pubmed/id/9249202

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1997-10-20
pubmed:abstractText
We compared and evaluated the duration of the post-antibiotic effect (PAE) of six anti-mycobacterial agents (ethambutol, isoniazid, rifampicin, amikacin, ciprofloxacin and clarithromycin), alone and in combination, against ten strains of Mycobacterium avium. PAE was determined by conventional viable counting and the Bactec growth system, analysed by the T100 value (the time to produce a cumulative growth index of 100). A 2 h exposure to the drug did not induce significant killing. Thus, comparison of regrowth could be evaluated without the potential need to adjust viable counts. The correlation of duration of PAE between the viable count method and the T100 Bactec method was excellent (r = 0.94). No significant PAE (< 8 h) was induced using sub-inhibitory drug concentrations or with ethambutol or isoniazid alone. Rifampicin (20-41 h) and amikacin (8-36 h) demonstrated consistent and extended PAEs, while ciprofloxacin (1-15 h) and clarithromycin (2-10 h) displayed variable PAE activities. Different three-drug combinations (all including ethambutol) displayed variable results with a combination of ethambutol, isoniazid and rifampicin being the most effective combination for extending the PAE (> or = 8 h) which was observed in half the strains tested. It was concluded that the T100 Bactec method is highly suitable for evaluating PAE against M. avium, producing a definitive result in 5 days.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0305-7453
pubmed:author
pubmed:issnType
Print
pubmed:volume
40
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
33-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Evaluation of the post-antibiotic effect of six anti-mycobacterial agents against Mycobacterium avium by the Bactec radiometric method.
pubmed:affiliation
Department of Mycobacteriology, Statens Serum Institut, Copenhagen S, Denmark.
pubmed:publicationType
Journal Article, Comparative Study