Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
1997-8-25
|
| pubmed:abstractText |
A major histocompatibility complex (MHC) class I-specific T cell receptor (TCR)-transgenic mouse was used to study classical-type transplantation tolerance in the adult. Engraftment of MHC class I-incompatible bone marrow and tolerance to donor-type skin grafts were obtained using dimethylmyeleran (DMM) as a myeloablative agent and a non-depleting anti-CD8 monoclonal antibody (mAb) as the sole immunosuppressant. Surprisingly, bone marrow engraftment was facilitated by host CD4+ T cells, a subset normally considered unable to reject class I MHC-incompatible grafts. A combination of mAb to interleukins (IL)-4 and -10 antagonized the "permissive" effects of host CD4+ T cells, indicating a possible role for Th2-type immunoregulation that can act on CD8+ T cells in this form of transplantation tolerance. The fate of graft-reactive T cells was monitored using anti-clonotypic antibodies. It was observed that bone marrow engraftment then led to peripheral deletion of mAb-blockaded, clonotype+ CD8+ T cells.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0014-2980
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
27
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1663-70
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9247575-Animals,
pubmed-meshheading:9247575-Antibodies, Blocking,
pubmed-meshheading:9247575-Antibodies, Monoclonal,
pubmed-meshheading:9247575-Bone Marrow Transplantation,
pubmed-meshheading:9247575-CD4-Positive T-Lymphocytes,
pubmed-meshheading:9247575-CD8-Positive T-Lymphocytes,
pubmed-meshheading:9247575-Clonal Deletion,
pubmed-meshheading:9247575-Cytokines,
pubmed-meshheading:9247575-Graft Enhancement, Immunologic,
pubmed-meshheading:9247575-Graft Rejection,
pubmed-meshheading:9247575-Immune Tolerance,
pubmed-meshheading:9247575-Lymphocyte Activation,
pubmed-meshheading:9247575-Lymphocyte Depletion,
pubmed-meshheading:9247575-Mice,
pubmed-meshheading:9247575-Mice, Inbred CBA,
pubmed-meshheading:9247575-Skin Transplantation,
pubmed-meshheading:9247575-Spleen,
pubmed-meshheading:9247575-Th2 Cells
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
A role for Th2 cytokines in the suppression of CD8+ T cell-mediated graft rejection.
|
| pubmed:affiliation |
Department of Pathology, University of Cambridge, GB.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|