Linked Life Data

9238713

Source:http://linkedlifedata.com/resource/pubmed/id/9238713

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1997-9-2
pubmed:abstractText
The transcription factor, nuclear factor-kappa-B (NF-kappa B), can be induced by pro-inflammatory cytokines and is important in immunological and inflammatory processes because it directs transcription of chemoattractants, cytokines (including the NF-kappa B-inducing cytokines themselves), cytokine receptors and cell adhesion molecules. We and others have recently found that NF-kappa B and the glucocorticoid or progesterone receptor mutually suppress each other's activity. Because of its central role in signal transduction in immunological and inflammatory responses, inhibition of NF-kappa B activity by glucocorticoids and progestins provides an explanation for the anti-inflammatory and immunosuppressive activity of these molecules. Since suppression of inflammatory processes leading to menstruation and parturition are among the key functions of progesterone, the repression of NF-kappa B activity by the progesterone receptor may prove to be essential in the regulation of these processes. Recent data show that it may be possible to select progesterone receptor ligands that are more efficient suppressors of NF-kappa B activity, and which may therefore be more effective in modulating these major reproductive processes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1360-9947
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
433-8
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Nuclear factor-kappa-B/steroid hormone receptor interactions as a functional basis of anti-inflammatory action of steroids in reproductive organs.
pubmed:affiliation
Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Utrecht, The Netherlands.
pubmed:publicationType
Journal Article, Review