Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
16
pubmed:dateCreated
1997-9-8
pubmed:abstractText
A M182T substitution was discovered as a second-site suppressor of a missense mutation in TEM-1 beta-lactamase. The combination of the M182T substitution with other substitutions in the enzyme indicates the M182T substitution is a global suppressor of missense mutations in beta-lactamase. The M182T substitution also is found in natural variants of TEM-1 beta-lactamase with altered substrate specificity that have evolved in response to antibiotic therapy. The M182T substitution may have been selected in natural isolates as a suppressor of folding or stability defects resulting from mutations associated with drug resistance. This pathway of protein evolution may occur in other targets of antimicrobial drugs such as the HIV protease.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9238058-1329081, http://linkedlifedata.com/resource/pubmed/commentcorrection/9238058-1952834, http://linkedlifedata.com/resource/pubmed/commentcorrection/9238058-2315699, http://linkedlifedata.com/resource/pubmed/commentcorrection/9238058-2513251, http://linkedlifedata.com/resource/pubmed/commentcorrection/9238058-2651442, http://linkedlifedata.com/resource/pubmed/commentcorrection/9238058-2658780, http://linkedlifedata.com/resource/pubmed/commentcorrection/9238058-2691474, http://linkedlifedata.com/resource/pubmed/commentcorrection/9238058-2934554, http://linkedlifedata.com/resource/pubmed/commentcorrection/9238058-3028975, http://linkedlifedata.com/resource/pubmed/commentcorrection/9238058-3323813, http://linkedlifedata.com/resource/pubmed/commentcorrection/9238058-3519625, http://linkedlifedata.com/resource/pubmed/commentcorrection/9238058-3896923, http://linkedlifedata.com/resource/pubmed/commentcorrection/9238058-4284300, http://linkedlifedata.com/resource/pubmed/commentcorrection/9238058-7038468, http://linkedlifedata.com/resource/pubmed/commentcorrection/9238058-7639844, http://linkedlifedata.com/resource/pubmed/commentcorrection/9238058-7700387, http://linkedlifedata.com/resource/pubmed/commentcorrection/9238058-7726509, http://linkedlifedata.com/resource/pubmed/commentcorrection/9238058-8057847, http://linkedlifedata.com/resource/pubmed/commentcorrection/9238058-8257123, http://linkedlifedata.com/resource/pubmed/commentcorrection/9238058-8356032, http://linkedlifedata.com/resource/pubmed/commentcorrection/9238058-8601776, http://linkedlifedata.com/resource/pubmed/commentcorrection/9238058-8637002, http://linkedlifedata.com/resource/pubmed/commentcorrection/9238058-8878598, http://linkedlifedata.com/resource/pubmed/commentcorrection/9238058-8891161, http://linkedlifedata.com/resource/pubmed/commentcorrection/9238058-942051
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
5
pubmed:volume
94
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
8801-6
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
A natural polymorphism in beta-lactamase is a global suppressor.
pubmed:affiliation
Department of Microbiology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.