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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1997-8-26
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pubmed:abstractText |
A specific monoclonal antibody against toxin A from Clostridium difficile was generated that did not show thermolabile binding. Nonspecific murine monoclonal antibodies bound toxin A at 4 degrees C, but less effectively at 37 degrees C. Nonspecific human monoclonal antibodies did not bind to toxin A at 4 degrees C. Cytotoxic properties of purified toxin A were not inhibited by Bandeiraea simplicifolia lectin. This points to a carbohydrate moiety on the cell surface and a multivalent nonspecific carbohydrate binding ligand on toxin A.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0041-0101
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
129-32
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:9237345-Animals,
pubmed-meshheading:9237345-Antibody Specificity,
pubmed-meshheading:9237345-Bacterial Toxins,
pubmed-meshheading:9237345-Binding Sites,
pubmed-meshheading:9237345-Carbohydrate Metabolism,
pubmed-meshheading:9237345-Cells, Cultured,
pubmed-meshheading:9237345-Cercopithecus aethiops,
pubmed-meshheading:9237345-Clostridium difficile,
pubmed-meshheading:9237345-Enterotoxins,
pubmed-meshheading:9237345-Female,
pubmed-meshheading:9237345-Humans,
pubmed-meshheading:9237345-Mice,
pubmed-meshheading:9237345-Mice, Inbred BALB C,
pubmed-meshheading:9237345-Receptors, Cell Surface,
pubmed-meshheading:9237345-Vero Cells
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pubmed:year |
1994
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pubmed:articleTitle |
Multivalent binding of toxin A from Clostridium difficile to carbohydrate receptors.
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pubmed:affiliation |
Eijkman-Winkler Laboratory for Medical Microbiology, Ultrecht, The Netherlands.
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pubmed:publicationType |
Journal Article
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