| pubmed-article:9234177 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9234177 | lifeskim:mentions | umls-concept:C1527169 | lld:lifeskim |
| pubmed-article:9234177 | lifeskim:mentions | umls-concept:C0013018 | lld:lifeskim |
| pubmed-article:9234177 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:9234177 | lifeskim:mentions | umls-concept:C0524864 | lld:lifeskim |
| pubmed-article:9234177 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9234177 | pubmed:dateCreated | 1997-10-16 | lld:pubmed |
| pubmed-article:9234177 | pubmed:abstractText | We studied peripheral blood and apheresis samples from 39 consecutive normal donors who were parents or siblings of patients who received matched or mismatched bone marrow transplants using a combination of rhG-CSF-mobilized peripheral blood stem cells (PBSCs) and bone marrow (BM). BM was harvested from donors 1-7 days before starting rhG-CSF treatment: 12 micrograms/kg/day rhG-CSF was administered by continuous s.c. infusion for 4-7 days. Peripheral blood progenitor cells were harvested by leukapheresis using an automated continuous-flow blood cell separator, beginning on day 4 of rhG/CSF, for 1-4 consecutive days. Peak peripheral blood CD34+ cell and CFU-GM levels were reached simultaneously on day 5 or 6 of rhG-CSF administration. Median peak levels were 1.65% for CD34+ cells (range 0.34%-4.7%) and 142 CFU-GM/10(5) plated cells (range 16-700). The greatest numbers of CD34+ cells and CFU-GM, expressed per liter of blood volume processed, were harvested during the second and third leukapheresis: CD34+ cells 37.77 +/- 25.48 x 10(6) and CFU-GM 3.32 +/- 2.51 x 10(6) during the second leukapheresis, and CD34+ cells 37.01 +/- 16.33 x 10(6) and CFU-GM 3.82 +/- 4.36 x 10(6) during the third. The number of CD34+ cells and CFU-GM did not correlate with the sex, age, or body weight of the donors. This study indicates that this protocol for administration of rhG-CSF mobilizes large numbers of hematopoietic progenitor cells into the peripheral blood and that bone marrow harvesting before G-CSF administration does not impair stem cell mobilization. | lld:pubmed |
| pubmed-article:9234177 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9234177 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9234177 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9234177 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9234177 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9234177 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:9234177 | pubmed:issn | 1061-6128 | lld:pubmed |
| pubmed-article:9234177 | pubmed:author | pubmed-author:MartelliM FMF | lld:pubmed |
| pubmed-article:9234177 | pubmed:author | pubmed-author:AversaFF | lld:pubmed |
| pubmed-article:9234177 | pubmed:author | pubmed-author:RossettiMM | lld:pubmed |
| pubmed-article:9234177 | pubmed:author | pubmed-author:CaputiVV | lld:pubmed |
| pubmed-article:9234177 | pubmed:author | pubmed-author:MartelliM PMP | lld:pubmed |
| pubmed-article:9234177 | pubmed:author | pubmed-author:TabilioAA | lld:pubmed |
| pubmed-article:9234177 | pubmed:author | pubmed-author:FalzettiFF | lld:pubmed |
| pubmed-article:9234177 | pubmed:author | pubmed-author:GiannoniCC | lld:pubmed |
| pubmed-article:9234177 | pubmed:author | pubmed-author:ChionneFF | lld:pubmed |
| pubmed-article:9234177 | pubmed:author | pubmed-author:GambelungheCC | lld:pubmed |
| pubmed-article:9234177 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9234177 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:9234177 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9234177 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9234177 | pubmed:pagination | 227-34 | lld:pubmed |
| pubmed-article:9234177 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9234177 | pubmed:meshHeading | pubmed-meshheading:9234177-... | lld:pubmed |
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| pubmed-article:9234177 | pubmed:meshHeading | pubmed-meshheading:9234177-... | lld:pubmed |
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| pubmed-article:9234177 | pubmed:meshHeading | pubmed-meshheading:9234177-... | lld:pubmed |
| pubmed-article:9234177 | pubmed:meshHeading | pubmed-meshheading:9234177-... | lld:pubmed |
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| pubmed-article:9234177 | pubmed:meshHeading | pubmed-meshheading:9234177-... | lld:pubmed |
| pubmed-article:9234177 | pubmed:meshHeading | pubmed-meshheading:9234177-... | lld:pubmed |
| pubmed-article:9234177 | pubmed:meshHeading | pubmed-meshheading:9234177-... | lld:pubmed |
| pubmed-article:9234177 | pubmed:meshHeading | pubmed-meshheading:9234177-... | lld:pubmed |
| pubmed-article:9234177 | pubmed:meshHeading | pubmed-meshheading:9234177-... | lld:pubmed |
| pubmed-article:9234177 | pubmed:meshHeading | pubmed-meshheading:9234177-... | lld:pubmed |
| pubmed-article:9234177 | pubmed:meshHeading | pubmed-meshheading:9234177-... | lld:pubmed |
| pubmed-article:9234177 | pubmed:meshHeading | pubmed-meshheading:9234177-... | lld:pubmed |
| pubmed-article:9234177 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9234177 | pubmed:articleTitle | Stem cell mobilization in normal donors. | lld:pubmed |
| pubmed-article:9234177 | pubmed:affiliation | Department of Clinical Medicine, Pathology, and Pharmacology, Haematology, University of Perugia, Italy. | lld:pubmed |
| pubmed-article:9234177 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9234177 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9234177 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9234177 | lld:pubmed |
