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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1997-8-12
|
| pubmed:abstractText |
The human immunodeficiency virus (HIV) epidemic is associated with a marked increase of tuberculosis cases. The influence of HIV on diagnostic methods for tuberculous lymphadenitis is less clear. In an environment of high HIV and tuberculosis prevalence in Blantyre, Malawi, a prospective study compared results of basic procedures diagnosing tuberculous lymphadenitis with the outcome of histology and/or culture. One hundred out-patients, aged 15-55 years, with extra-inguinal lymphadenopathy not responding to general antibiotics, entered the study. Among 52 cases, with whom all procedures were carried out in accordance with the protocol, 38 (73%) were diagnosed as tuberculous lymphadenitis; 84% of the latter (32/38) were seropositive for HIV. Needle aspirate and biopsy smears stained by the Ziehl-Neelsen technique contributed little to detecting tuberculosis, 8% and 11% respectively. In contrast, macroscopic caseation of excised lymph nodes showed a high yield of 82%, which was similar to histology, and higher than that of Löwenstein-Jensen culture (61%). The study suggested that HIV positivity of tuberculous lymphadenitis patients decreased the possibility of histology and culture both being indicative of tuberculosis (odds ratio 0.10; P = 0.06). Consequently histology results, often used as the single definitive method, failed to diagnose 18% (7/38) of tuberculosis cases. However, it was reassuring that 4 simple methods, which can safely be carried out at district level, could be expected to diagnose 80-95% of tuberculous lymphadenitis cases in a timely and cost-effective manner.
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| pubmed:keyword |
http://linkedlifedata.com/resource/pubmed/keyword/Acquired Immunodeficiency Syndrome,
http://linkedlifedata.com/resource/pubmed/keyword/Africa,
http://linkedlifedata.com/resource/pubmed/keyword/Africa South Of The Sahara,
http://linkedlifedata.com/resource/pubmed/keyword/Clinical Research,
http://linkedlifedata.com/resource/pubmed/keyword/Developing Countries,
http://linkedlifedata.com/resource/pubmed/keyword/Diseases,
http://linkedlifedata.com/resource/pubmed/keyword/Eastern Africa,
http://linkedlifedata.com/resource/pubmed/keyword/English Speaking Africa,
http://linkedlifedata.com/resource/pubmed/keyword/Examinations And Diagnoses,
http://linkedlifedata.com/resource/pubmed/keyword/Hiv Infections,
http://linkedlifedata.com/resource/pubmed/keyword/Infections,
http://linkedlifedata.com/resource/pubmed/keyword/Laboratory Examinations And Diagnoses,
http://linkedlifedata.com/resource/pubmed/keyword/Malawi,
http://linkedlifedata.com/resource/pubmed/keyword/Measurement,
http://linkedlifedata.com/resource/pubmed/keyword/Prevalence,
http://linkedlifedata.com/resource/pubmed/keyword/Research Methodology,
http://linkedlifedata.com/resource/pubmed/keyword/Research Report,
http://linkedlifedata.com/resource/pubmed/keyword/TUBERCULOSIS,
http://linkedlifedata.com/resource/pubmed/keyword/Viral Diseases
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0035-9203
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
91
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
294-7
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:otherAbstract |
PIP: A prospective study conducted in 1994-95 in Blantyre, Malawi, investigated the influence of HIV on diagnostic methods for tuberculous lymphadenitis in 100 outpatients 15-55 years old with extra-inguinal lymphadenopathy not responsive to general antibiotics. For the 52 cases for which all diagnostic procedures were carried out, 38 (73%) were diagnosed as tuberculous lymphadenitis; 32 (84%) of these patients were HIV-positive. Needle aspirate and biopsy smears stained by the Ziehl-Neelsen technique contributed only 8% and 11%, respectively, to detecting tuberculosis. In contrast, macroscopic caseation of excised lymph nodes, histology, and Lowenstein-Jensen culture had yields of 82%, 82%, and 61%, respectively. These findings indicate that, in tuberculous lymphadenitis patients, HIV infection decreases the diagnostic power of culture and histology. However, use of the other methods can diagnose 80-95% of tuberculous lymphadenitis cases in a cost-effective manner in areas with high prevalences of both HIV and tuberculosis.
|
| pubmed:meshHeading |
pubmed-meshheading:9231200-Adolescent,
pubmed-meshheading:9231200-Adult,
pubmed-meshheading:9231200-Biopsy, Needle,
pubmed-meshheading:9231200-HIV Seropositivity,
pubmed-meshheading:9231200-Humans,
pubmed-meshheading:9231200-Lymph Nodes,
pubmed-meshheading:9231200-Malawi,
pubmed-meshheading:9231200-Middle Aged,
pubmed-meshheading:9231200-Predictive Value of Tests,
pubmed-meshheading:9231200-Prospective Studies,
pubmed-meshheading:9231200-Sensitivity and Specificity,
pubmed-meshheading:9231200-Tuberculosis, Lymph Node
|
| pubmed:articleTitle |
Tuberculous lymphadenitis, a diagnostic problem in areas of high prevalence of HIV and tuberculosis.
|
| pubmed:affiliation |
Regional Health Office, Blantyre, Malawi.
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| pubmed:publicationType |
Journal Article
|