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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
3
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|
pubmed:dateCreated |
1997-9-5
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|
pubmed:abstractText |
It is well established that peripheral dopamine receptors activation evokes vasodilation and neurohormonal modulation. Z1046 is a potent mixed dopaminergic agonist and is highly selective over adrenergic and serotoninergic (5-HT2) activities. In contrast, dopamine had agonist activities on all adrenergic receptors while it is known that dopexamine has a beta 2 agonist activity and is an inhibitor of the neuronal uptake. As far as fenoldopam is concerned, selective stimulation of D1-like receptors leads to an increase of renin release. In conclusion, Z1046 is a potent and specific drug for dopamine receptors. This profile makes Z1046 different from other dopaminergic agents.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:issn |
0231-424X
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
84
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
283-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9219608-Animals,
pubmed-meshheading:9219608-Arteries,
pubmed-meshheading:9219608-Dopamine,
pubmed-meshheading:9219608-Dopamine Agonists,
pubmed-meshheading:9219608-Dopamine Antagonists,
pubmed-meshheading:9219608-Ear,
pubmed-meshheading:9219608-Fenoldopam,
pubmed-meshheading:9219608-Male,
pubmed-meshheading:9219608-Naphthols,
pubmed-meshheading:9219608-Rabbits,
pubmed-meshheading:9219608-Spleen
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|
pubmed:year |
1996
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|
pubmed:articleTitle |
Z1046: a new specific peripheral dopaminergic compound.
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pubmed:affiliation |
Zambon Group, Bresso, Milan, Italy.
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pubmed:publicationType |
Journal Article,
In Vitro
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