rdf:type |
|
lifeskim:mentions |
umls-concept:C0006142,
umls-concept:C0033684,
umls-concept:C0175630,
umls-concept:C0205179,
umls-concept:C0242957,
umls-concept:C0441889,
umls-concept:C0681842,
umls-concept:C0854638,
umls-concept:C0871261,
umls-concept:C1516213,
umls-concept:C1517050,
umls-concept:C1550147,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
|
pubmed:issue |
7
|
pubmed:dateCreated |
1997-7-25
|
pubmed:abstractText |
Overexpression of the HER-2/c-neu/c-erbB2 proto-oncogene is associated with a worse prognosis in patients with breast cancer, perhaps due to an association of the HER-2 proto-oncogene protein with resistance to hormone and/or chemotherapy. Circulating levels of the extracellular domain (ECD) of the HER-2/c-neu-related protein (NRP) are elevated in 20% to 40% of patients with metastatic breast cancer. We investigated whether pretreatment levels of NRP predict response to hormone therapy (HT).
|
pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jul
|
pubmed:issn |
0732-183X
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
15
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
2518-25
|
pubmed:dateRevised |
2009-11-19
|
pubmed:meshHeading |
pubmed-meshheading:9215820-Aged,
pubmed-meshheading:9215820-Antineoplastic Agents, Hormonal,
pubmed-meshheading:9215820-Breast Neoplasms,
pubmed-meshheading:9215820-Female,
pubmed-meshheading:9215820-Humans,
pubmed-meshheading:9215820-Logistic Models,
pubmed-meshheading:9215820-Middle Aged,
pubmed-meshheading:9215820-Odds Ratio,
pubmed-meshheading:9215820-Predictive Value of Tests,
pubmed-meshheading:9215820-Proportional Hazards Models,
pubmed-meshheading:9215820-Receptor, erbB-2,
pubmed-meshheading:9215820-Treatment Outcome
|
pubmed:year |
1997
|
pubmed:articleTitle |
Prediction of response to antiestrogen therapy in advanced breast cancer patients by pretreatment circulating levels of extracellular domain of the HER-2/c-neu protein.
|
pubmed:affiliation |
Lombardi Cancer Center, Department of Medicine, Georgetown University Medical Center, Washington, DC, USA.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|