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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
1997-9-24
|
| pubmed:abstractText |
The purpose of this study was to investigate the effects of 3 different types of flow generation for cardiopulmonary bypass on gastrointestinal permeability and on neutrophil expression of CD11b, a surface marker of neutrophil activation. Fourteen patients undergoing elective coronary revascularization were selected randomly to receive 1 of the 3 flow generation techniques (roller, pulsatile, or centrifugal). Intestinal permeability was assessed by the fraction of an oral dose of 51chromium-ethylenediaminetetraacetate (51Cr-EDTA) recovered in the urine over 24 h. Neutrophil activation was determined by expression of CD11b markers at 6 time points. Overall, the 14 patients showed significant increases in intestinal permeability. It was not possible to demonstrate statistically significant differences among the flow generation groups; however, when compared to both roller pump groups, the centrifugal pump group showed a 3.2% reduction in intestinal permeability. There was no change in the expression of CD11b receptors throughout the time points, nor was there a relationship of CD11b markers to the flow generation technique.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0160-564X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
21
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
825-9
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9212967-Administration, Oral,
pubmed-meshheading:9212967-Aged,
pubmed-meshheading:9212967-Cardiopulmonary Bypass,
pubmed-meshheading:9212967-Chromium Radioisotopes,
pubmed-meshheading:9212967-Coronary Artery Bypass,
pubmed-meshheading:9212967-Digestive System,
pubmed-meshheading:9212967-Edetic Acid,
pubmed-meshheading:9212967-Electrocardiography,
pubmed-meshheading:9212967-Female,
pubmed-meshheading:9212967-Hematocrit,
pubmed-meshheading:9212967-Humans,
pubmed-meshheading:9212967-Intestinal Absorption,
pubmed-meshheading:9212967-Isotope Labeling,
pubmed-meshheading:9212967-Macrophage-1 Antigen,
pubmed-meshheading:9212967-Male,
pubmed-meshheading:9212967-Middle Aged,
pubmed-meshheading:9212967-Neutrophil Activation,
pubmed-meshheading:9212967-Neutrophils,
pubmed-meshheading:9212967-Permeability,
pubmed-meshheading:9212967-Pulsatile Flow
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Prevention of remote organ injury in cardiopulmonary bypass: the impact of flow generation technique.
|
| pubmed:affiliation |
Department of Cardiothoracic Surgery, Queen Elizabeth Medical Center, United Kingdom.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial
|