Linked Life Data

9207174

Source:http://linkedlifedata.com/resource/pubmed/id/9207174

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1997-7-24
pubmed:abstractText
Structural and functional alterations of cell membranes caused by free radicals leading to lipid peroxidation and increases in intracellular Ca2+ concentrations have been implicated in atherogenesis. The objective of this study was to directly measure the effects of a major aldehydic lipid peroxidation product, 4-OH-nonenal (HNE), on plasma membrane Ca2+ regulatory mechanisms. This was attained by measuring passive Ca2+ permeability, primary active Ca2+-transport, and (Ca2+ + Mg2+)-ATPase activity in a human red cell model system. Using this three-pronged approach it could be shown that HNE increases passive Ca2+ permeability significantly beyond the typically low basal flux, while at the same time inhibiting the active Ca2+ extrusion pump and associated (Ca2+ + Mg2+)-ATPase activity. We conclude that this deleterious combination of effects by HNE in this plasma membrane model system may be indicative of plasma membrane changes in cells directly involved in atheroma formation and thus may represent causative factors in the early stages of atherogenesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0006-291X
pubmed:author
pubmed:issnType
Print
pubmed:day
27
pubmed:volume
235
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
451-4
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Effects of 4-OH-2,3-trans-nonenal on human erythrocyte plasma membrane Ca2+ pump and passive Ca2+ permeability.
pubmed:affiliation
Department of Pharmacology and Toxicology, Indiana University School of Medicine, Evansville 47712, USA.
pubmed:publicationType
Journal Article