Linked Life Data

9207000

Source:http://linkedlifedata.com/resource/pubmed/id/9207000

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:9207000rdf:typepubmed:Citationlld:pubmed
pubmed-article:9207000lifeskim:mentionsumls-concept:C0014644lld:lifeskim
pubmed-article:9207000lifeskim:mentionsumls-concept:C0021311lld:lifeskim
pubmed-article:9207000lifeskim:mentionsumls-concept:C0034790lld:lifeskim
pubmed-article:9207000lifeskim:mentionsumls-concept:C1704632lld:lifeskim
pubmed-article:9207000lifeskim:mentionsumls-concept:C0871261lld:lifeskim
pubmed-article:9207000lifeskim:mentionsumls-concept:C0036576lld:lifeskim
pubmed-article:9207000lifeskim:mentionsumls-concept:C0205322lld:lifeskim
pubmed-article:9207000lifeskim:mentionsumls-concept:C2911692lld:lifeskim
pubmed-article:9207000lifeskim:mentionsumls-concept:C1706817lld:lifeskim
pubmed-article:9207000lifeskim:mentionsumls-concept:C0443288lld:lifeskim
pubmed-article:9207000lifeskim:mentionsumls-concept:C0205250lld:lifeskim
pubmed-article:9207000lifeskim:mentionsumls-concept:C1880371lld:lifeskim
pubmed-article:9207000pubmed:issue1lld:pubmed
pubmed-article:9207000pubmed:dateCreated1997-8-1lld:pubmed
pubmed-article:9207000pubmed:abstractTextThe T cell receptor (TCR) repertoires of cytotoxic responses to the immunodominant and subdominant HLA A11-restricted epitopes in the Epstein-Barr virus (EBV) nuclear antigen-4 were investigated in four healthy virus carriers. The response to the subdominant epitope (EBNA4 399-408, designated AVF) was highly restricted with conserved Vbeta usage and identical length and amino acid motifs in the third complementarity-determining regions (CDR3), while a broad repertoire using different combinations of TCR-alpha/beta V and J segments and CDR3 regions was selected by the immunodominant epitope (EBNA4 416-424, designated IVT). Distinct patterns of interaction with the A11-peptide complex were revealed for each AVF- or IVT-specific TCR clonotype by alanine scanning mutagenesis analysis. Blocking of cytotoxic function by antibodies specific for the CD8 coreceptor indicated that, while AVF-specific TCRs are of high affinity, the oligoclonal response to the IVT epitope includes both low- and high-affinity TCRs. Thus, comparison of the memory response to two epitopes derived from the same viral antigen and presented through the same MHC class I allele suggests that immunodominance may correlate with the capacity to maintain a broad TCR repertoire.lld:pubmed
pubmed-article:9207000pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9207000pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9207000pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9207000pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9207000pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9207000pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9207000pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9207000pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9207000pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9207000pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9207000pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9207000pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9207000pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9207000pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9207000pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9207000pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9207000pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9207000pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9207000pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9207000pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9207000pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9207000pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9207000pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9207000pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9207000pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9207000pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9207000pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9207000pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9207000pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9207000pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9207000pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9207000pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9207000pubmed:languageenglld:pubmed
pubmed-article:9207000pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9207000pubmed:citationSubsetIMlld:pubmed
pubmed-article:9207000pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9207000pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9207000pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9207000pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9207000pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9207000pubmed:statusMEDLINElld:pubmed
pubmed-article:9207000pubmed:monthJullld:pubmed
pubmed-article:9207000pubmed:issn0022-1007lld:pubmed
pubmed-article:9207000pubmed:authorpubmed-author:MasucciM GMGlld:pubmed
pubmed-article:9207000pubmed:authorpubmed-author:GavioliRRlld:pubmed
pubmed-article:9207000pubmed:authorpubmed-author:LevitskyVVlld:pubmed
pubmed-article:9207000pubmed:authorpubmed-author:ImrehM PMPlld:pubmed
pubmed-article:9207000pubmed:authorpubmed-author:Campos-LimaP...lld:pubmed
pubmed-article:9207000pubmed:issnTypePrintlld:pubmed
pubmed-article:9207000pubmed:day7lld:pubmed
pubmed-article:9207000pubmed:volume186lld:pubmed
pubmed-article:9207000pubmed:ownerNLMlld:pubmed
pubmed-article:9207000pubmed:authorsCompleteYlld:pubmed
pubmed-article:9207000pubmed:pagination83-9lld:pubmed
pubmed-article:9207000pubmed:dateRevised2011-11-17lld:pubmed
pubmed-article:9207000pubmed:meshHeadingpubmed-meshheading:9207000-...lld:pubmed
pubmed-article:9207000pubmed:meshHeadingpubmed-meshheading:9207000-...lld:pubmed
pubmed-article:9207000pubmed:meshHeadingpubmed-meshheading:9207000-...lld:pubmed
pubmed-article:9207000pubmed:meshHeadingpubmed-meshheading:9207000-...lld:pubmed
pubmed-article:9207000pubmed:meshHeadingpubmed-meshheading:9207000-...lld:pubmed
pubmed-article:9207000pubmed:meshHeadingpubmed-meshheading:9207000-...lld:pubmed
pubmed-article:9207000pubmed:meshHeadingpubmed-meshheading:9207000-...lld:pubmed
pubmed-article:9207000pubmed:meshHeadingpubmed-meshheading:9207000-...lld:pubmed
pubmed-article:9207000pubmed:meshHeadingpubmed-meshheading:9207000-...lld:pubmed
pubmed-article:9207000pubmed:meshHeadingpubmed-meshheading:9207000-...lld:pubmed
pubmed-article:9207000pubmed:meshHeadingpubmed-meshheading:9207000-...lld:pubmed
pubmed-article:9207000pubmed:meshHeadingpubmed-meshheading:9207000-...lld:pubmed
pubmed-article:9207000pubmed:meshHeadingpubmed-meshheading:9207000-...lld:pubmed
pubmed-article:9207000pubmed:year1997lld:pubmed
pubmed-article:9207000pubmed:articleTitleEpitope-dependent selection of highly restricted or diverse T cell receptor repertoires in response to persistent infection by Epstein-Barr virus.lld:pubmed
pubmed-article:9207000pubmed:affiliationMicrobiology and Tumor Biology Center, Karolinska Institute, S-171 77, Stockholm, Sweden.lld:pubmed
pubmed-article:9207000pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:9207000pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9207000lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9207000lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9207000lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9207000lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9207000lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9207000lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9207000lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9207000lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9207000lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9207000lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9207000lld:pubmed
More...