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rdf:type |
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lifeskim:mentions |
umls-concept:C0014644,
umls-concept:C0021311,
umls-concept:C0034790,
umls-concept:C0036576,
umls-concept:C0205250,
umls-concept:C0205322,
umls-concept:C0443288,
umls-concept:C0871261,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1880371,
umls-concept:C2911692
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pubmed:issue |
1
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pubmed:dateCreated |
1997-8-1
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pubmed:abstractText |
The T cell receptor (TCR) repertoires of cytotoxic responses to the immunodominant and subdominant HLA A11-restricted epitopes in the Epstein-Barr virus (EBV) nuclear antigen-4 were investigated in four healthy virus carriers. The response to the subdominant epitope (EBNA4 399-408, designated AVF) was highly restricted with conserved Vbeta usage and identical length and amino acid motifs in the third complementarity-determining regions (CDR3), while a broad repertoire using different combinations of TCR-alpha/beta V and J segments and CDR3 regions was selected by the immunodominant epitope (EBNA4 416-424, designated IVT). Distinct patterns of interaction with the A11-peptide complex were revealed for each AVF- or IVT-specific TCR clonotype by alanine scanning mutagenesis analysis. Blocking of cytotoxic function by antibodies specific for the CD8 coreceptor indicated that, while AVF-specific TCRs are of high affinity, the oligoclonal response to the IVT epitope includes both low- and high-affinity TCRs. Thus, comparison of the memory response to two epitopes derived from the same viral antigen and presented through the same MHC class I allele suggests that immunodominance may correlate with the capacity to maintain a broad TCR repertoire.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9207000-1321426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9207000-1591001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9207000-1901079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9207000-222691,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9207000-2385109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9207000-2440339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9207000-3016710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9207000-3043226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9207000-3208747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9207000-3298007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9207000-3866244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9207000-6176881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9207000-7500015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9207000-7511684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9207000-7541822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9207000-7545110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9207000-7679748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9207000-7682013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9207000-7734044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9207000-7916949,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9207000-7964506,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9207000-8056033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9207000-8064237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9207000-8124703,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9207000-8188290,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9207000-8384718,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9207000-8550092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9207000-8642295,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9207000-8671682,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9207000-8920868,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9207000-8920869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9207000-8955273
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
186
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
83-9
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:9207000-Amino Acid Sequence,
pubmed-meshheading:9207000-Antigens, Viral,
pubmed-meshheading:9207000-Cells, Cultured,
pubmed-meshheading:9207000-HLA-A Antigens,
pubmed-meshheading:9207000-HLA-A11 Antigen,
pubmed-meshheading:9207000-Herpesviridae Infections,
pubmed-meshheading:9207000-Herpesvirus 4, Human,
pubmed-meshheading:9207000-Humans,
pubmed-meshheading:9207000-Immunodominant Epitopes,
pubmed-meshheading:9207000-Molecular Sequence Data,
pubmed-meshheading:9207000-Receptors, Antigen, T-Cell,
pubmed-meshheading:9207000-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:9207000-Tumor Virus Infections
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pubmed:year |
1997
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pubmed:articleTitle |
Epitope-dependent selection of highly restricted or diverse T cell receptor repertoires in response to persistent infection by Epstein-Barr virus.
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pubmed:affiliation |
Microbiology and Tumor Biology Center, Karolinska Institute, S-171 77, Stockholm, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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