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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1997-7-24
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pubmed:abstractText |
The role of hypercorticism in the development of compromised beta-adrenergic signaling in adipose tissue was assessed in ob/ob mice adrenalectomized at 4 weeks of age and studied 1 and 3 weeks thereafter. Adrenalectomy prevented the rapid increase in body weight and fat deposition between 4 and 5 weeks of age in ob/ob mice and produced a phenotype indistinguishable from that of lean mice. However, adrenalectomized ob/ob mice became intermediate between lean and ob/ob mice by 7 weeks of age. Adipocyte beta3-adrenergic receptor (AR) messenger RNA levels were similar between lean and adrenalectomized ob/ob mice at both time points and were 4- to 8-fold higher than messenger RNA levels in ob/ob mice. As judged by maximal activation of adenylyl cyclase by a beta3-AR-selective agonist, adrenalectomy also restored functional activity of the beta3-AR to levels above or equivalent to those seen in lean mice at both time points. The present results suggest that development of hypercorticism at or before weaning in ob/ob mice represses expression of the beta3-AR and prevents the normal postweaning development of this signaling system in the adipocyte.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic beta-Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic beta-Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/CGP 20712A,
http://linkedlifedata.com/resource/pubmed/chemical/CL 316243,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP,
http://linkedlifedata.com/resource/pubmed/chemical/Dioxoles,
http://linkedlifedata.com/resource/pubmed/chemical/Epinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Imidazoles,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, beta,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, beta-3,
http://linkedlifedata.com/resource/pubmed/chemical/Ribonucleases
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0013-7227
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
138
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2697-704
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9202206-Adipocytes,
pubmed-meshheading:9202206-Adrenal Glands,
pubmed-meshheading:9202206-Adrenalectomy,
pubmed-meshheading:9202206-Adrenergic beta-Agonists,
pubmed-meshheading:9202206-Adrenergic beta-Antagonists,
pubmed-meshheading:9202206-Animals,
pubmed-meshheading:9202206-Binding, Competitive,
pubmed-meshheading:9202206-Binding Sites,
pubmed-meshheading:9202206-Cyclic AMP,
pubmed-meshheading:9202206-Dioxoles,
pubmed-meshheading:9202206-Epinephrine,
pubmed-meshheading:9202206-Imidazoles,
pubmed-meshheading:9202206-Mice,
pubmed-meshheading:9202206-Mice, Inbred C57BL,
pubmed-meshheading:9202206-Mice, Obese,
pubmed-meshheading:9202206-RNA, Messenger,
pubmed-meshheading:9202206-Receptors, Adrenergic, beta,
pubmed-meshheading:9202206-Receptors, Adrenergic, beta-3,
pubmed-meshheading:9202206-Ribonucleases,
pubmed-meshheading:9202206-Signal Transduction,
pubmed-meshheading:9202206-Stereoisomerism,
pubmed-meshheading:9202206-Weaning
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pubmed:year |
1997
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pubmed:articleTitle |
Adrenalectomy after weaning restores beta3-adrenergic receptor expression in white adipocytes from C57BL/6J-ob/ob mice.
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pubmed:affiliation |
Department of Medicine, Medical University of South Carolina, Charleston 29425, USA. Gettystw@musc.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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