Linked Life Data

9191862

Source:http://linkedlifedata.com/resource/pubmed/id/9191862

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1997-7-7
pubmed:abstractText
Although the rabies virus P and M genes, encoding the viral phosphoprotein and matrix protein respectively, have been characterised for a few laboratory-adapted strains, there is essentially no information on the variability of these two genes in wild-type rabies viruses. In this study rabies viruses, responsible for epizootics in different wildlife species in three geographically distinct areas of North America, have been characterised at the P and M gene loci. These data reveal that the M gene and its encoded product are much more conserved than the P gene and its encoded phosphoprotein. The latter product harbors two variable domains which contribute to different hydropathy profiles for this protein for each of the rabies virus strains studied. Phylogenetic analysis of the nucleotide sequences generated in this study, together with data generated previously on the N and G genes of these rabies virus strains, indicated that similar evolutionary relationships are predicted regardless of the portion of the viral genome targeted.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0304-8608
pubmed:author
pubmed:issnType
Print
pubmed:volume
142
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
979-92
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Polymorphism of rabies viruses within the phosphoprotein and matrix protein genes.
pubmed:affiliation
Rabies Unit, Agriculture and Agri-Food Canada, Nepean, Ontario, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't