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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
12
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pubmed:dateCreated |
1997-7-7
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pubmed:abstractText |
We confirm that IL-10 is produced comparatively late after the activation of human T cells via CD3 stimulation, after IL-2 and IFN-gamma. Furthermore we show that IL-10 production by human T cell lines, such as IFN-gamma and IL-2, is inhibited by the immunosuppressive drugs cyclosporin A and FK506. However, a third immunosuppressive drug, rapamycin, normally associated with inhibiting the effects, but not the production, of cytokines, inhibited IL-10, but not IFN-gamma, production. This implies that IL-10 induction may be a secondary event in T cell activation. Since IL-2 is the major growth factor for T cells and is detected before IL-10, we focused on this factor as a potential activator of IL-10 production. We showed that IL-10 production by human T cell lines stimulated by immobilized anti-CD3 in the presence of neutralizing Abs to IL-2 and IL-2R (anti-CD25) was inhibited, whereas addition of exogenous IL-2 enhanced IL-10 production, indicating that IL-10 production by human T cells can be driven by stimulation via IL-2. As the IL-2R shares the common gamma-chain component with IL-4, IL-7, and IL-15, we investigated the possibility that they may all enhance anti-CD3-induced IL-10 production and established that this was the case. Since IL-10 has been previously described as a direct inhibitor of Ag presentation and of IL-2 production, our finding that IL-2 is capable of inducing its own inhibitor demonstrates a feedback mechanism within the immune system that could limit ongoing T cell activation and possibly inflammation.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclosporine,
http://linkedlifedata.com/resource/pubmed/chemical/Immunosuppressive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-10,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-12,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Polyenes,
http://linkedlifedata.com/resource/pubmed/chemical/Sirolimus,
http://linkedlifedata.com/resource/pubmed/chemical/Tacrolimus
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-1767
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
158
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
5596-602
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9190906-Antigens, CD3,
pubmed-meshheading:9190906-Cells, Cultured,
pubmed-meshheading:9190906-Cyclosporine,
pubmed-meshheading:9190906-Humans,
pubmed-meshheading:9190906-Immunosuppressive Agents,
pubmed-meshheading:9190906-Interleukin-10,
pubmed-meshheading:9190906-Interleukin-12,
pubmed-meshheading:9190906-Interleukin-2,
pubmed-meshheading:9190906-Lymphocyte Activation,
pubmed-meshheading:9190906-Polyenes,
pubmed-meshheading:9190906-Sirolimus,
pubmed-meshheading:9190906-T-Lymphocytes,
pubmed-meshheading:9190906-Tacrolimus
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pubmed:year |
1997
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pubmed:articleTitle |
Autocrine and paracrine regulation of human T cell IL-10 production.
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pubmed:affiliation |
Kennedy Institute of Rheumatology and The Anthony Nolan Bone Marrow Trust and the Department of Hematology, The Royal Free Hospital, London, United Kingdom. Shara@rfhsm.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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