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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1997-7-8
|
| pubmed:abstractText |
Migration to the intima and other responses of M-SMC in the rat carotid artery and abdominal aorta after balloon injury were investigated in vivo. Migration occurred intensively between the second and fifth days after injury. About 80% of the cells were in the G1 and S phases of the cell cycle. The majority of the migrating cells were therefore simultaneously proliferating. Positive values of 42.3%, 48.9%, 44.4%, and 32.8% of the migrating cells on the fifth day in the carotid artery for PDGF-B, elastase III B, MMP-I, and MMP-9, were observed, respectively. Many of the cells expressed messages of PDGF-A and elastases II and III B by in situ hybridization. Fine structures of the migrating cells were characterized as a synthetic phenotype of the smooth muscle cell with reduced attachment to their surrounding ECM. A biphasic proliferative response of the M-SMC appeared on the second and fifth days. Migration occurred correspondingly in the proliferative period. The populations of M-SMC positive in immunostainings for PDGFs, their receptors, elastase III B, and MMP-1 and MMP-9 also increased biphasically, around 12 h and five days after the injury. The results of these studies suggest that the migrating cells were proliferative and synthesizing PDGFs, elastases, and collagenases.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0077-8923
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
811
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
459-70
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:9186623-Angioplasty, Balloon,
pubmed-meshheading:9186623-Animals,
pubmed-meshheading:9186623-Carotid Arteries,
pubmed-meshheading:9186623-Cell Division,
pubmed-meshheading:9186623-Cell Movement,
pubmed-meshheading:9186623-Male,
pubmed-meshheading:9186623-Muscle, Smooth, Vascular,
pubmed-meshheading:9186623-Rats,
pubmed-meshheading:9186623-Rats, Wistar,
pubmed-meshheading:9186623-Tunica Intima,
pubmed-meshheading:9186623-Tunica Media
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Migration of medial smooth muscle cells to the intima after balloon injury.
|
| pubmed:affiliation |
Department of Pathology, Yamanashi Medical University, Japan.
|
| pubmed:publicationType |
Journal Article
|