|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
1997-7-21
|
|
pubmed:abstractText |
Phosphodiesterase type 4 (PDE4) plays a major role in modulating the activity of virtually all cells involved in the inflammatory process. Inhibitors of this enzyme family display impressive anti-inflammatory and disease-modifying effects in a variety of experimental models. In this review, Mauro Teixeira, Robert Gristwood, Nicola Cooper and Paul Hellewell examine the capacity of PDE4 inhibitors to exert anti-inflammatory actions in vivo and discuss the potential of this class of drugs to take their place as novel therapeutic agents for a variety of inflammatory diseases.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0165-6147
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
18
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
164-71
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:9184477-3',5'-Cyclic-AMP Phosphodiesterases,
pubmed-meshheading:9184477-Animals,
pubmed-meshheading:9184477-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:9184477-Cyclic Nucleotide Phosphodiesterases, Type 4,
pubmed-meshheading:9184477-Humans,
pubmed-meshheading:9184477-Isoenzymes,
pubmed-meshheading:9184477-Phosphodiesterase Inhibitors,
pubmed-meshheading:9184477-Phosphoric Diester Hydrolases
|
|
pubmed:year |
1997
|
|
pubmed:articleTitle |
Phosphodiesterase (PDE)4 inhibitors: anti-inflammatory drugs of the future?
|
|
pubmed:affiliation |
Imperial College of Medicine, National Heart and Lung Institute, London, UK.
|
|
pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
|
