Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1997-7-2
|
| pubmed:abstractText |
A 47-year-old man with acute myeloblastic leukemia (AML) developed angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) 4 months after induction chemotherapy for AML. During a leukopenic period, the patient suffered from pericarditis with massive pericardial effusion in which human herpesvirus 6 (HHV-6) DNA was detected. Although complete remission of AML was achieved, fever persisted and atypical skin rash followed by generalized lymphadenopathy along with polyclonal hypergammaglobulinemia appeared. A diagnosis of AILD was made on a biopsy specimen of the inguinal lymph node. The patient died of fulminant hepatitis and the autopsy showed lymphomatous infiltrates involving the liver, bone marrow, lungs, spleen, kidneys and heart. HHV-6 DNA sequences were identified in the biopsy specimen of the lymph node and in the involved organ tissues. HHV-6 in this patient was variant B. It is known that HHV-6 can be reactivated in immunocompromised patients and causes severe complications. This unusual clinical course suggests that the immunosuppression associated with AML and the additional iatrogenic immunosuppression following cytopenia-inducing chemotherapy predisposed the patient to reactivated HHV-6 infection. The sequential detection of this virus before and after manifestation of AILD may support the evidence that HHV-6 infection could directly or indirectly trigger AILD. This is the first time that such a sequence of events has been reported to our knowledge. The possibility of HHV-6 infection should be considered when unexplained fever and generalized lymphadenopathy are seen in patients with leukemia, and administration of antiviral agents should be considered for the diagnostic evaluation.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0887-6924
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
11
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
882-5
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9177444-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:9177444-Autopsy,
pubmed-meshheading:9177444-Cytarabine,
pubmed-meshheading:9177444-DNA, Viral,
pubmed-meshheading:9177444-Fatal Outcome,
pubmed-meshheading:9177444-Fever,
pubmed-meshheading:9177444-Herpesviridae Infections,
pubmed-meshheading:9177444-Herpesvirus 6, Human,
pubmed-meshheading:9177444-Humans,
pubmed-meshheading:9177444-Hypergammaglobulinemia,
pubmed-meshheading:9177444-Idarubicin,
pubmed-meshheading:9177444-Immunoblastic Lymphadenopathy,
pubmed-meshheading:9177444-Immunophenotyping,
pubmed-meshheading:9177444-Leukemia, Myeloid, Acute,
pubmed-meshheading:9177444-Lymph Nodes,
pubmed-meshheading:9177444-Male,
pubmed-meshheading:9177444-Middle Aged,
pubmed-meshheading:9177444-Pericarditis,
pubmed-meshheading:9177444-Polymerase Chain Reaction,
pubmed-meshheading:9177444-Remission Induction,
pubmed-meshheading:9177444-Tumor Virus Infections
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Angioimmunoblastic lymphadenopathy with disseminated human herpesvirus 6 infection in a patient with acute myeloblastic leukemia.
|
| pubmed:affiliation |
Department of Medicine, Kochi Medical School, Japan.
|
| pubmed:publicationType |
Journal Article,
Case Reports
|