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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1997-7-10
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pubmed:abstractText |
Expression of endothelin (ET) receptor subtypes was examined in an experimental model of A375 human melanoma cell differentiation using the pyrimidine analog bromodeoxyuridine (BUdR). BUdR (10 microM)-treated cells had an increased surface area and an increased dendricity, were contact-inhibited and lacked tumorigenecity in athymic nude mice. The untreated A375 cells exclusively expressed ETB and BUdR-induced phenotypical changes were accompanied by induction of ETA expression as evidenced by northern blotting, [125I]ET-1 binding assay and [Ca2+]i measurement. Thus, BUdR-induced differentiation of A375 melanoma cells may provide a model system to study the receptor subtype switch in melanocyte development.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bromodeoxyuridine,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Endothelin-1,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Endothelin A,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Endothelin
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
19
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pubmed:volume |
234
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
526-30
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:9177306-Animals,
pubmed-meshheading:9177306-Bromodeoxyuridine,
pubmed-meshheading:9177306-Calcium,
pubmed-meshheading:9177306-Cell Differentiation,
pubmed-meshheading:9177306-Endothelin-1,
pubmed-meshheading:9177306-Gene Expression,
pubmed-meshheading:9177306-Humans,
pubmed-meshheading:9177306-Melanocytes,
pubmed-meshheading:9177306-Melanoma,
pubmed-meshheading:9177306-Mice,
pubmed-meshheading:9177306-Mice, Nude,
pubmed-meshheading:9177306-Models, Biological,
pubmed-meshheading:9177306-Phenotype,
pubmed-meshheading:9177306-RNA, Messenger,
pubmed-meshheading:9177306-RNA, Neoplasm,
pubmed-meshheading:9177306-Receptor, Endothelin A,
pubmed-meshheading:9177306-Receptors, Endothelin,
pubmed-meshheading:9177306-Tumor Cells, Cultured
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pubmed:year |
1997
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pubmed:articleTitle |
Bromodeoxyuridine-induced expression of endothelin A in A375 human melanoma cells.
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pubmed:affiliation |
Department of Pharmacology, Faculty of Medicine, Kyoto University, Japan.
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pubmed:publicationType |
Journal Article
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