Linked Life Data

9176114

Source:http://linkedlifedata.com/resource/pubmed/id/9176114

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1997-6-23
pubmed:abstractText
This study examined the development and persistence of immunity in humans presenting defined states of Onchocerca volvulus infection, i.e. in exposed endemic control individuals without microfilaridermia and clinical disease, in patients with patent or post-patent onchocerciasis, and in patients concurrently infected with Mansonella perstans. Onchocerca volvulus antigen (OvAg)-specific cellular reactivity was significantly diminished in microfilariae (mf)-positive patients, while the highest reactivity was measured in exposed but mf-negative endemic controls, those being free of any clinical signs of onchocercal disease. In patients who became post-patent, responses to OvAg were significantly augmented, but did not approach entirely the magnitude observed in endemic controls. In onchocerciasis patients with concurrent mansonelliasis, cellular unresponsiveness to OvAg persisted, even when mf of O. volvulus were eliminated permanently by repeated ivermectin therapy. Cells from mf-positive onchocerciasis patients produced significantly less interferon-gamma (IFN-gamma) (P < 0.01) and interleukin-5 (IL-5) (P < 0.05) in response to OvAg than those taken from endemic controls or post-patent individuals in whom IFN-gamma and IL-5 production was similarly high. In contrast, both OvAg-driven as well as spontaneous IL-10 secretion was higher in mf-positive patients than in endemic controls or post-patent cases. In all individuals examined, serological recognition of OvAg by immunoglobulins was dominated by IgG4; in mf-positive patients OvAg of 205,000-12,000 molecular weight (MW) were strongly bound. In post-patent individuals, and similarly in endemic controls. OvAg recognition by IgG4 varied from intense (with numerous antigens being recognized) to weak or absent antigen binding. Significantly elevated OvAg-specific IgG isotypes were measured in mf-positive onchocerciasis patients in comparison with endemic controls or post-patent individuals (with the exception of IgG3). IgG1, IgG2 and IgE were higher, but IgG4 was lower in endemic controls compared with post-patent onchocerciasis patients. The ratios of IgG4/IgG1 differed (P < 0.001) between endemic controls and mf-positive or post-patent onchocerciasis patients, with IgG4/IgG1 ratios of R < 3.0 being characteristic for endemic controls and post-patent O. volvulus infection. In conclusion, this cross-sectional immunoepidemiological investigation showed that distinct states of O. volvulus infection correlate with a particular cellular and humoral immune response. The mf-free condition appeared to be associated with a vigorous parasite-specific cellular reactivity and a particular cytokine production profile, while concurrent M. perstans infection depressed OvAg-specific cellular responsiveness. Antibody responses, in all likelihood, reflected the intensity and state of infection, and not the degree of acquired immunity protective against parasite aggregation.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9176114-1363185, http://linkedlifedata.com/resource/pubmed/commentcorrection/9176114-1492378, http://linkedlifedata.com/resource/pubmed/commentcorrection/9176114-1516257, http://linkedlifedata.com/resource/pubmed/commentcorrection/9176114-1572089, http://linkedlifedata.com/resource/pubmed/commentcorrection/9176114-1589302, http://linkedlifedata.com/resource/pubmed/commentcorrection/9176114-2019761, http://linkedlifedata.com/resource/pubmed/commentcorrection/9176114-2033268, http://linkedlifedata.com/resource/pubmed/commentcorrection/9176114-2051025, http://linkedlifedata.com/resource/pubmed/commentcorrection/9176114-2393979, http://linkedlifedata.com/resource/pubmed/commentcorrection/9176114-2642916, http://linkedlifedata.com/resource/pubmed/commentcorrection/9176114-2894134, http://linkedlifedata.com/resource/pubmed/commentcorrection/9176114-3125261, http://linkedlifedata.com/resource/pubmed/commentcorrection/9176114-6861374, http://linkedlifedata.com/resource/pubmed/commentcorrection/9176114-7276574, http://linkedlifedata.com/resource/pubmed/commentcorrection/9176114-7561696, http://linkedlifedata.com/resource/pubmed/commentcorrection/9176114-7876612, http://linkedlifedata.com/resource/pubmed/commentcorrection/9176114-7876613, http://linkedlifedata.com/resource/pubmed/commentcorrection/9176114-8187332, http://linkedlifedata.com/resource/pubmed/commentcorrection/9176114-8337736, http://linkedlifedata.com/resource/pubmed/commentcorrection/9176114-8408619, http://linkedlifedata.com/resource/pubmed/commentcorrection/9176114-8413664, http://linkedlifedata.com/resource/pubmed/commentcorrection/9176114-8648219, http://linkedlifedata.com/resource/pubmed/commentcorrection/9176114-8699070, http://linkedlifedata.com/resource/pubmed/commentcorrection/9176114-8706329, http://linkedlifedata.com/resource/pubmed/commentcorrection/9176114-8769619
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0019-2805
pubmed:author
pubmed:issnType
Print
pubmed:volume
90
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
592-9
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
The diverse expression of immunity in humans at distinct states of Onchocerca volvulus infection.
pubmed:affiliation
Institute of Tropical Medicine, University Tübingen, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't