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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1997-8-7
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pubmed:abstractText |
In order to investigate the role of Bcl-2 in dopaminergic cells, we established a dopaminergic neuronal cell line (MN9D) stably expressing human Bcl-2 (MN9D/Bcl-2) or neomycin (MN9D/Neo). Overexpression of Bcl-2 in MN9D cells attenuated cell death due to treatment of mitochondrial electron transport inhibitors including N-methyl-4-phenylpyridinium, whereas it did not prevent cell death induced by reagents generating reactive oxygen species including 6-hydroxy-dopamine. Moreover, the rate of glucose uptake in MN9D/Bcl-2 was significantly lower than that in MN9D/Neo after MPP+ treatment. Thus, Bcl-2 may counter aberrations in mitochondrial electron transfer processes by altering energy metabolism within the MN9D cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0969-9961
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
157-67
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9173999-1-Methyl-4-phenylpyridinium,
pubmed-meshheading:9173999-Antibodies, Monoclonal,
pubmed-meshheading:9173999-Blotting, Western,
pubmed-meshheading:9173999-Cell Culture Techniques,
pubmed-meshheading:9173999-Cell Death,
pubmed-meshheading:9173999-Cell Survival,
pubmed-meshheading:9173999-Gene Expression,
pubmed-meshheading:9173999-Glucose,
pubmed-meshheading:9173999-Humans,
pubmed-meshheading:9173999-Immunochemistry,
pubmed-meshheading:9173999-Oxidopamine,
pubmed-meshheading:9173999-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:9173999-Rhodamine 123,
pubmed-meshheading:9173999-Rhodamines
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pubmed:year |
1995
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pubmed:articleTitle |
Overexpression of Bcl-2 attenuates MPP+, but not 6-ODHA, induced cell death in a dopaminergic neuronal cell line.
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pubmed:affiliation |
Department of Biology, Yonsei University School of Natural Sciences, Seoul, Korea.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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