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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1997-6-19
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pubmed:databankReference |
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/D13942,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/J02227,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/J02288,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/J02400,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/K02449,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M20322,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M20775,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M35834,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M57473,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U21836,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U21837,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U21838,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U21839,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U21840,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U21841,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U21842,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U21843,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U21844,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U73178,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U73500,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/V01108,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X02449
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pubmed:abstractText |
The central demyelinating disease progressive multifocal leukoencephalopathy (PML) is caused by the human polyomavirus JC virus (JCV). JCV evolved as geographically based genotypes of which Type 3 is an African variant first characterized in HIV-1 positive patients from Tanzania. This study reports the complete sequence of five JCV Type 3 strains. The entire JCV genome was PCR amplified from urine specimens of three African and two African-American individuals. The African consensus sequence was compared to the Type 1 and Type 2 prototype strains, JCV (Mad-1) and JCV(GS/B), respectively. Type 3 differed in 2.2% of its coding region genome from JCV (Mad-1) and in 1.3% from JCV(GS/B). Within the coding region the sequence variation among the three types was higher in the capsid protein VP1 and in the regulatory protein large T antigen than in the agnoprotein or in VP2/3. Notable Type 3-specific changes were located at sites adjacent to the zinc finger motif and near the major donor and acceptor splice junctions of large T antigen. Four of the five urinary Type 3 strains had an unrearranged, archetypal regulatory region. African strain #309 showed a 10-bp deletion at a location similar to that previously described for #307 from Tanzania. The African-American Type 3 strain #312 was closely related to the African consensus sequence. The complete genome of a urinary JCV strain from another African-American male, previously reported as a possible Type 5, showed a sequence difference of only 0.52% from the Tanzanian consensus and has been reclassified as a subtype of Type 3.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0304-8608
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
142
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
637-55
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9170494-African Continental Ancestry Group,
pubmed-meshheading:9170494-Amino Acid Sequence,
pubmed-meshheading:9170494-Base Sequence,
pubmed-meshheading:9170494-DNA, Viral,
pubmed-meshheading:9170494-Genome, Viral,
pubmed-meshheading:9170494-Humans,
pubmed-meshheading:9170494-JC Virus,
pubmed-meshheading:9170494-Male,
pubmed-meshheading:9170494-Molecular Sequence Data,
pubmed-meshheading:9170494-Regulatory Sequences, Nucleic Acid,
pubmed-meshheading:9170494-Replication Origin,
pubmed-meshheading:9170494-Sequence Homology, Amino Acid,
pubmed-meshheading:9170494-Sequence Homology, Nucleic Acid,
pubmed-meshheading:9170494-Species Specificity,
pubmed-meshheading:9170494-Tanzania,
pubmed-meshheading:9170494-United States,
pubmed-meshheading:9170494-Viral Proteins
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pubmed:year |
1997
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pubmed:articleTitle |
Five complete genomes of JC virus type 3 from Africans and African Americans.
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pubmed:affiliation |
Laboratory of Experimental Neuropathology, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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